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Neural Plasticity
Volume 2008 (2008), Article ID 108969, 8 pages
http://dx.doi.org/10.1155/2008/108969
Research Article

Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks

1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
2Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, 5 Sanbancho Chiyoda-ku, Tokyo 102-00075, Japan

Received 13 January 2008; Revised 10 April 2008; Accepted 13 May 2008

Academic Editor: Clive Bramham

Copyright © 2008 Atsushi Usami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditions, spontaneous activity was increased in active cell number and activity frequency. When ionic compositions were restored to the control conditions, the activity level returned to baseline, but the weighted spatial dispersion of active cells, as assessed by entropy-based metrics, did not. Thus, the networks can modify themselves by altering the internal structure of their correlated activity, even though they as a whole maintained the same level of activity in space and time.