The Role of -Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations
Figure 2
Antagonizing GLUK5-containing
KARs with UBP302 inhibits kainate-driven gamma frequency oscillations in the MEC. (a)
Extracellular field recordings showing 1 second epochs of activity (i)
in the presence of 400 nM kainate, (ii) following 10 μM UBP302 application, and (iii) during a
washout period into 400 nM kainate. (b) Pooled power spectra (n = 9) produced from 60
second epochs of extracellular field recorded data, showing a control recording
(black), a recording in the presence of 400 nM kainate (blue), application of 10 μM UBP302 (green), and washout back into 400 nM
kainate (red). Scale bar represents 200 milliseconds
and 100 μV.
