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Neural Plasticity
Volume 2015, Article ID 414173, 9 pages
Review Article

Retrosplenial Cortex and Long-Term Memory: Molecules to Behavior

Department of Psychological and Brain Sciences, Dartmouth College, Hanover 03755, NH, USA

Received 11 December 2014; Accepted 13 March 2015

Academic Editor: Jorge H. Medina

Copyright © 2015 Travis P. Todd and David J. Bucci. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The retrosplenial cortex (RSC) is reciprocally connected with the hippocampus and various parahippocampal cortical regions, suggesting that RSC is well-positioned to contribute to hippocampal-dependent memory. Consistent with this, substantial behavioral evidence indicates that RSC is essential for consolidating and/or retrieving contextual and spatial memories. In addition, there is growing evidence that RSC neurons undergo activity-dependent plastic changes during memory formation and retrieval. In this paper we review both the behavioral and cellular/molecular data and posit that the RSC has a particularly important role in the storage and retrieval of spatial and contextual memories perhaps due its involvement in binding together multiple cues in the environment. We identify remaining questions and avenues for future research that take advantage of emerging methods to selectively manipulate RSC neurons both spatially and temporally and to image the RSC in awake, behaving animals.