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Neural Plasticity
Volume 2015, Article ID 503079, 10 pages
http://dx.doi.org/10.1155/2015/503079
Research Article

Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine

1Department of Neurology, Goethe University, 60590 Frankfurt am Main, Germany
2Institute of General Pharmacology and Toxicology, Goethe University, 60590 Frankfurt am Main, Germany
3Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt am Main, Germany
4Department of Internal Medicine I, Goethe University, 60590 Frankfurt am Main, Germany
5Institute of Forensic Medicine, Goethe University, 60590 Frankfurt am Main, Germany

Received 30 January 2015; Accepted 6 April 2015

Academic Editor: Michael S. Beattie

Copyright © 2015 R. Brunkhorst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Methods 1 and 2 describe the mass-spectrometry methods for measuring sphingolipids as well as fluoxetine. Supplemental Figure 1 shows the tissue used for biochemical analysis, Supplemental Figure 2 shows the applied control experiments for validation of the ASM-Assay, Supplemental Figure 3 displays the most important lipids and enzymes of the ceramide metabolism.

  1. Supplementary Material