Multiscale Modeling Indicates That Temperature Dependent [Ca²⁺]_i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Figure 4

Spike width and amplitude in dependence on the pump strength for the Ca²⁺ signal shown in Figure 3. (a) The spike width exhibits an exponential dependence on . This is in good agreement with the experimental findings in Figure 1. (b) Also the amplitude dependence on obeys an exponential relation (error bars denote s.e.).

(a)

(b)