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Neural Plasticity
Volume 2015, Article ID 717958, 13 pages
http://dx.doi.org/10.1155/2015/717958
Review Article

Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting

Suk-yu Yau,1,2 Ang Li,1,3,4,5 and Kwok-Fai So1,3,4,6

1State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
2Division of Medical Sciences, University of Victoria, Victoria, BC, Canada V8P 5C2
3Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
4Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou 510632, China
5Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
6Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong

Received 28 December 2014; Revised 12 March 2015; Accepted 31 March 2015

Academic Editor: Pedro Bekinschtein

Copyright © 2015 Suk-yu Yau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how this small number of newborn neurons could affect learning and memory remains unclear. In this review, we discuss the relationship between adult-born neurons and learning and memory, with a highlight on recently discovered potential roles of neurogenesis in pattern separation and forgetting.