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Neural Plasticity
Volume 2016, Article ID 8580675, 9 pages
http://dx.doi.org/10.1155/2016/8580675
Research Article

Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST

1Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Shandong University School of Life Sciences, Jinan, Shandong 250100, China
2Taishan Medical University, Tai’an, Shandong 271000, China
3School of Life Sciences, Tsinghua University, Beijing 100084, China

Received 18 July 2016; Accepted 26 September 2016

Academic Editor: Renjie Chai

Copyright © 2016 Hongyun Nie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. G. Gillespie and U. Müller, “Mechanotransduction by hair cells: models, molecules, and mechanisms,” Cell, vol. 139, no. 1, pp. 33–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Goodyear, W. Marcotti, C. J. Kros, and G. P. Richardson, “Development and properties of stereociliary link types in hair cells of the mouse cochlea,” Journal of Comparative Neurology, vol. 485, no. 1, pp. 75–85, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. A. Assad, G. M. Shepherd, and D. P. Corey, “Tip-link integrity and mechanical transduction in vertebrate hair cells,” Neuron, vol. 7, no. 6, pp. 985–994, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Beurg, R. Fettiplace, J.-H. Nam, and A. J. Ricci, “Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging,” Nature Neuroscience, vol. 12, no. 5, pp. 553–558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Siemens, C. Lillo, R. A. Dumont et al., “Cadherin 23 is a component of the tip link in hair-cell stereocilla,” Nature, vol. 428, no. 6986, pp. 950–955, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. M. Ahmed, R. Goodyear, S. Riazuddin et al., “The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15,” The Journal of Neuroscience, vol. 26, no. 26, pp. 7022–7034, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Kazmierczak, H. Sakaguchi, J. Tokita et al., “Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells,” Nature, vol. 449, no. 7158, pp. 87–91, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. D. N. Furness, Y. Katori, B. Nirmal Kumar, and C. M. Hackney, “The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium,” Neuroscience, vol. 154, no. 1, pp. 10–21, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Sotomayor, W. A. Weihofen, R. Gaudet, and D. P. Corey, “Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction,” Nature, vol. 492, no. 7427, pp. 128–132, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. M. Ahmed, S. Riazuddin, S. L. Bernstein et al., “Mutations of the protocadherin gene PCDH15 cause usher syndrome type 1F,” The American Journal of Human Genetics, vol. 69, no. 1, pp. 25–34, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. K. N. Alagramam, H. Yuan, M. H. Kuehn et al., “Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F,” Human Molecular Genetics, vol. 10, no. 16, pp. 1709–1718, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. M. Ahmed, S. Riazuddin, J. Ahmad et al., “PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23,” Human Molecular Genetics, vol. 12, no. 24, pp. 3215–3223, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. K. N. Alagramam, C. L. Murcia, H. Y. Kwon, K. S. Pawlowski, C. G. Wright, and R. P. Woychik, “The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene,” Nature Genetics, vol. 27, no. 1, pp. 99–102, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. Q. Y. Zheng, H. Yu, J. L. Washington III et al., “A new spontaneous mutation in the mouse protocadherin 15 gene,” Hearing Research, vol. 219, no. 1-2, pp. 110–120, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. K. N. Alagramam, R. J. Goodyear, R. Geng et al., “Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells,” PLoS ONE, vol. 6, no. 4, Article ID e19183, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. W. Webb, N. Grillet, L. R. Andrade et al., “Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain,” Development, vol. 138, no. 8, pp. 1607–1617, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Pepermans, V. Michel, R. Goodyear et al., “The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells,” EMBO Molecular Medicine, vol. 6, no. 7, pp. 984–992, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Xiong, N. Grillet, H. M. Elledge et al., “TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells,” Cell, vol. 151, no. 6, pp. 1283–1295, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Zhao, Z. Wu, N. Grillet et al., “TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells,” Neuron, vol. 84, no. 5, pp. 954–967, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Maeda, K. S. Kindt, W. Mo et al., “Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 35, pp. 12907–12912, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Beurg, W. Xiong, B. Zhao, U. Müller, and R. Fettiplace, “Subunit determination of the conductance of hair-cell mechanotransducer channels,” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 5, pp. 1589–1594, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Adato, V. Michel, Y. Kikkawa et al., “Interactions in the network of Usher syndrome type 1 proteins,” Human Molecular Genetics, vol. 14, no. 3, pp. 347–356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Reiners, T. Märker, K. Jürgens, B. Reidel, and U. Wolfrum, “Photoreceptor expression of the Usher syndrome type 1 protein protocadherin 15 (USH1F) and its interaction with the scaffold protein harmonin (USH1C),” Molecular Vision, vol. 11, pp. 347–355, 2005. View at Google Scholar · View at Scopus
  24. D. Yan, K. Kamiya, X. M. Ouyang, and X. Z. Liu, “Analysis of subcellular localization of Myo7a, Pcdh15 and Sans in Ush1c knockout mice,” International Journal of Experimental Pathology, vol. 92, no. 1, pp. 66–71, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Senften, M. Schwander, P. Kazmierczak et al., “Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells,” The Journal of Neuroscience, vol. 26, no. 7, pp. 2060–2071, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Grati, D. Yan, M. H. Raval et al., “MYO3A causes human dominant deafness and interacts with protocadherin 15-CD2 isoform,” Human Mutation, vol. 37, no. 5, pp. 481–487, 2016. View at Publisher · View at Google Scholar
  27. Z. Xu, A. W. Peng, K. Oshima, and S. Heller, “MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23,” Journal of Neuroscience, vol. 28, no. 44, pp. 11269–11276, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Cao, X. Yin, Y. Cao et al., “FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro,” PLoS ONE, vol. 8, no. 2, Article ID e56516, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Heller, C. A. Sheane, Z. Javed, and A. J. Hudspeth, “Molecular markers for cell types of the inner ear and candidate genes for hearing disorders,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 19, pp. 11400–11405, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Yao, T. Maeda, S. Takada, and T. Noda, “Identification of a PDZ domain containing golgi protein, GOPC, as an interaction partner of frizzled,” Biochemical and Biophysical Research Communications, vol. 286, no. 4, pp. 771–778, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Wente, T. Stroh, A. Beaudet, D. Richter, and H.-J. Kreienkamp, “Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5,” The Journal of Biological Chemistry, vol. 280, no. 37, pp. 32419–32425, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Koliwer, M. Park, C. Bauch, M. Von Zastrow, and H.-J. Kreienkamp, “The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-Adrenergic receptor in intracellular compartments after internalization,” Journal of Biological Chemistry, vol. 290, no. 10, pp. 6120–6129, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. Z. Xu, K. Oshima, and S. Heller, “PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23,” BMC Cell Biology, vol. 11, article 80, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Sheng and C. Sala, “PDZ domains and the organization of supramolecular complexes,” Annual Review of Neuroscience, vol. 24, pp. 1–29, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. V. Michel, R. J. Goodyear, D. Weil et al., “Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells,” Developmental Biology, vol. 280, no. 2, pp. 281–294, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Lagziel, Z. M. Ahmed, J. M. Schultz, R. J. Morell, I. A. Belyantseva, and T. B. Friedman, “Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development,” Developmental Biology, vol. 280, no. 2, pp. 295–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Zallocchi, D. T. Meehan, D. Delimont et al., “Role for a novel Usher protein complex in hair cell synaptic maturation,” PLoS ONE, vol. 7, no. 2, Article ID e30573, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Zallocchi, D. Delimont, D. T. Meehan, and D. Cosgrove, “Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells,” Journal of Neuroscience, vol. 32, no. 40, pp. 13841–13859, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Lu, L. Stewart, and J. M. Wilson, “Scaffolding protein GOPC regulates tight junction structure,” Cell and Tissue Research, vol. 360, no. 2, pp. 321–332, 2015. View at Publisher · View at Google Scholar · View at Scopus