The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer’s Disease

Table 3

Mean V1 thickness (), V1 [11C]-PiB SUVR (), V1 [11C]-PK11195 BP_ND (), and retinal layers thicknesses () per group. V1 [11C]-PiB uptake showed stark differences in Aβ load.

Variable	AD group ()	HC group ()	value
V1 (mm)	1.974 (0.114)	1.957 (0.133)	0.719
V1 [11C]-PiB SUVR	1.4350 (0.290)	1.033 (0.156)	<0.0001
V1 [11C]- PK11195 BPND	0.196 (0.060)	0.205 (0.058)	0.603
GCL (μm)	41.19 (3.59)	42.067 (3.99)	0.488
IPL (μm)	36.70 (3.16)	36.15 (2.80)	0.579
INL (μm)	36.82 (1.99)	36.50 (2.10)	0.646
OPL (μm)	30.42 (3.97)	28.41 (2.17)	0.104

V1: primary visual cortex; [11C]-PiB SUVR: Aβ PET radiotracer; [11C]-PK11195 BP_ND: neuroinflammation PET radiotracer binding potential; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; Bonferroni corrected for multiple comparisons.