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Obstetrics and Gynecology International
Volume 2014 (2014), Article ID 976321, 12 pages
http://dx.doi.org/10.1155/2014/976321
Review Article

Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside

Campus Clinic Gynecology, Ruhr-University Bochum, Universitätsstraße 140, 44799 Bochum, Germany

Received 26 September 2013; Accepted 28 December 2013; Published 20 February 2014

Academic Editor: Brian J. Koos

Copyright © 2014 A. Jensen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

About 17 million people worldwide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral palsy by transplantation of autologous umbilical cord blood. There are only 4 publications available at present; however, the observations made along with experimental data in vivo and in vitro may be of utmost importance clinically, so that a review at an early developmental stage of this new therapeutic concept seems justified. Particularly, since the first published double-blind randomized placebo-controlled trial in a paradigm using allogeneic cord blood and erythropoietin to treat cerebral palsy under immunosuppression showed beneficial therapeutic effects in infantile cerebral palsy, long-held doubts about the efficacy of this new cell therapy are dispelled and a revision of therapeutic views upon an ailment, for which there is no cure at present, is warranted. Hence, this review will summarize the available information on autologous cord blood therapy for cerebral palsy and that on the relevant experimental work as far as potential mechanisms and modes of action are concerned.