Figure 2: Head circumference determines white matter damage (WMD) assessed by cranial ultrasound in 4,725 term-born neonates. A parabolic correlation curve was fitted to describe the relation between head circumference (HC) in centiles and the risk to develop white matter damage (%): WMD (%) = 3.1168–0.12797HC (centile) + 0.0014741HC2 (centile) (r = 0.957, ). Interestingly, from all growth variables at birth, only head circumference showed a close relation to the risk of white matter damage over the whole range of centiles (Table 2).