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Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 718976, 7 pages
Review Article

Alterations in Nitric Oxide Synthase in the Aged CNS

Department of Anatomy, College of Medicine, Kyung Hee University, Heoki-Dong 1, Dongdaemun-Gu, Seoul 130-701, Republic of Korea

Received 13 February 2012; Revised 3 May 2012; Accepted 5 June 2012

Academic Editor: Marcos Dias Pereira

Copyright © 2012 Junyang Jung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric oxide (NO) production contributes to the aging process. However, it is still unclear how NO plays a role in the aging process. This paper describes age-related changes in the activity of NADPH-diaphorase (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS), in many CNS regions. Understanding these changes may provide a novel perspective in identifying the aging mechanism.