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Linked References

1. D. Harman, “The free radical theory of aging,” Antioxidants and Redox Signaling, vol. 5, no. 5, pp. 557–561, 2003. View at Google Scholar · View at Scopus
2. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press, New York, NY, USA, 3rd edition, 2004.
3. A. M. Florea, E. N. Yamoah, and E. Dopp, “Intracellular calcium disturbances induced by arsenic and its methylated derivatives in relation to genomic damage and apoptosis induction,” Environmental Health Perspectives, vol. 113, no. 6, pp. 659–664, 2005. View at Publisher · View at Google Scholar · View at Scopus
4. S. E. Boley, V. A. Wong, J. E. French, and L. Recio, “p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene,” Toxicological Sciences, vol. 66, no. 2, pp. 209–215, 2002. View at Publisher · View at Google Scholar · View at Scopus
5. R. Barouki, “Ageing free radicals and cellular stress,” Medecine/Sciences, vol. 22, no. 3, pp. 266–272, 2006. View at Google Scholar · View at Scopus
6. E. Moustacchi, “DNA damage and repair: consequences on dose-responses,” Mutation Research, vol. 464, no. 1, pp. 35–40, 2000. View at Publisher · View at Google Scholar · View at Scopus
7. C. Bernstein, H. Bernstein, C. M. Payne, and H. Garewal, “DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis,” Mutation Research, vol. 511, no. 2, pp. 145–178, 2002. View at Publisher · View at Google Scholar · View at Scopus
8. T. Nakano, A. Katafuchi, H. Terato, T. Suzuki, B. Van Houten, and H. Ide, “Activity of nucleotide excision repair enzymes for oxanine cross-link lesions,” Nucleic Acids Symposium Series, no. 49, pp. 293–294, 2005. View at Google Scholar · View at Scopus
9. T. A. Kunkel and D. A. Erie, “DNA mismatch repair,” Annual Review of Biochemistry, vol. 74, pp. 681–710, 2005. View at Publisher · View at Google Scholar · View at Scopus
10. J. Jiricny, “MutLα: at the cutting edge of mismatch repair,” Cell, vol. 126, no. 2, pp. 239–241, 2006. View at Publisher · View at Google Scholar · View at Scopus
11. D. Kültz, “Molecular and evolutionary basis of the cellular stress response,” Annual Review of Physiology, vol. 67, pp. 225–257, 2005. View at Publisher · View at Google Scholar · View at Scopus
12. D. N. Mullins, E. L. Crawford, S. A. Khuder, D. A. Hernandez, Y. Yoon, and J. C. Willey, “CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma_aptad 20050829,” BMC Cancer, vol. 5, article 141, 2005. View at Publisher · View at Google Scholar · View at Scopus
13. P. Peltomäki, “Deficient DNA mismatch repair: a common etiologic factor for colon cancer,” Human Molecular Genetics, vol. 10, no. 7, pp. 735–740, 2001. View at Google Scholar · View at Scopus
14. S. Santucci-Darmanin and V. Paquis-Flucklinger, “Homologs of MutS and MutL during mammalian meiosis,” Medecine Sciences, vol. 19, no. 1, pp. 85–91, 2003. View at Google Scholar · View at Scopus
15. Q. H. Phung, D. B. Winter, R. Alrefai, and P. J. Gearhart, “Cutting edge: hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein,” Journal of Immunology, vol. 162, no. 6, pp. 3121–3124, 1999. View at Google Scholar · View at Scopus
16. H. Saribasak, D. Rajagopal, R. W. Maul, and P. J. Gearhart, “Hijacked DNA repair proteins and unchained DNA polymerases,” Philosophical Transactions of the Royal Society B, vol. 364, no. 1517, pp. 605–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
17. H. Geng, M. Sakato, V. DeRocco, et al., “Biochemical analysis of the human mismatch repair proteins hMutSα MSH2^G674A-MSH6 and MSH2-MSH6^T1219D,” Journal of Biological Chemistry, vol. 287, no. 13, pp. 9777–9791, 2012. View at Google Scholar
18. Z. Hong, J. Jiang, K. Hashiguchi, M. Hoshi, L. Lan, and A. Yasui, “Recruitment of mismatch repair proteins to the site of DNA damage in human cells,” Journal of Cell Science, vol. 121, no. 19, pp. 3146–3154, 2008. View at Publisher · View at Google Scholar · View at Scopus
19. S. V. Mudrak, C. Welz-Voegele, and S. Jinks-Robertson, “The polymerase η translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast,” Molecular and Cellular Biology, vol. 29, no. 19, pp. 5316–5326, 2009. View at Publisher · View at Google Scholar · View at Scopus
20. F. J. López de Saro, “Regulation of interactions with sliding clamps during DNA replication and repair,” Current Genomics, vol. 10, no. 3, pp. 206–215, 2009. View at Publisher · View at Google Scholar · View at Scopus
21. Y. Zhang, F. Yuan, S. R. Presnell et al., “Reconstitution of $5^{\prime }$-directed human mismatch repair in a purified system,” Cell, vol. 122, no. 5, pp. 693–705, 2005. View at Publisher · View at Google Scholar · View at Scopus
22. N. Constantin, L. Dzantiev, F. A. Kadyrov, and P. Modrich, “Human mismatch repair: reconstitution of a nick-directed bidirectional reaction,” Journal of Biological Chemistry, vol. 280, no. 48, pp. 39752–39761, 2005. View at Publisher · View at Google Scholar · View at Scopus
23. L. Dzantiev, N. Constantin, J. Genschel, R. R. Iyer, P. M. Burgers, and P. Modrich, “A defined human system that supports bidirectional mismatch-provoked excision,” Molecular Cell, vol. 15, no. 1, pp. 31–41, 2004. View at Publisher · View at Google Scholar · View at Scopus
24. Y. Lin and J. H. Wilson, “Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells,” DNA Repair, vol. 8, no. 8, pp. 878–885, 2009. View at Publisher · View at Google Scholar · View at Scopus
25. H. Alazzouzi, E. Domingo, S. González et al., “Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis,” Human Molecular Genetics, vol. 14, no. 2, pp. 235–239, 2005. View at Publisher · View at Google Scholar · View at Scopus
26. P. Modrich and R. Lahue, “Mismatch repair in replication fidelity, genetic recombination, and cancer biology,” Annual Review of Biochemistry, vol. 65, pp. 101–133, 1996. View at Google Scholar · View at Scopus
27. A. D. Auerbach and P. C. Verlander, “Disorders of DNA replication and repair,” Current Opinion in Pediatrics, vol. 9, no. 6, pp. 600–616, 1997. View at Google Scholar · View at Scopus
28. Z. Yang, R. Lau, J. L. Marcadier, D. Chitayat, and C. E. Pearson, “Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells,” American Journal of Human Genetics, vol. 73, no. 5, pp. 1092–1105, 2003. View at Publisher · View at Google Scholar · View at Scopus
29. K. A. Narine, K. E. Felton, A. A. Parker, V. A. Tron, and S. E. Andrew, “Non-tumor cells from an MSH2-null individual show altered cell cycle effects post-UVB,” Oncology Reports, vol. 18, no. 6, pp. 1403–1411, 2007. View at Google Scholar · View at Scopus
30. C. S. Sørensen, L. T. Hansen, J. Dziegielewski et al., “The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair,” Nature Cell Biology, vol. 7, no. 2, pp. 195–201, 2005. View at Publisher · View at Google Scholar · View at Scopus
31. V. Leung-Pineda, C. E. Ryan, and H. Piwnica-Worms, “Phosphorylation of Chk1 by ATR is antagonized by a chk1-regulated protein phosphatase 2A circuit,” Molecular and Cellular Biology, vol. 26, no. 20, pp. 7529–7538, 2006. View at Publisher · View at Google Scholar · View at Scopus
32. M. Seifert, S. J. Scherer, W. Edelmann et al., “The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells,” Journal of Investigative Dermatology, vol. 128, no. 1, pp. 203–213, 2008. View at Publisher · View at Google Scholar · View at Scopus
33. L. C. Young, K. J. Thulien, M. R. Campbell, V. A. Tron, and S. E. Andrew, “DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study,” Carcinogenesis, vol. 25, no. 10, pp. 1821–1827, 2004. View at Publisher · View at Google Scholar · View at Scopus
34. M. Kappeler, E. Kranz, K. Woolcock, O. Georgiev, and W. Schaffner, “Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences,” Nucleic Acids Research, vol. 36, no. 21, pp. 6907–6917, 2008. View at Publisher · View at Google Scholar · View at Scopus
35. A. M. Skinner and M. S. Turker, “Oxidative mutagenesis, mismatch repair, and aging,” Science of Aging Knowledge Environment, vol. 2005, no. 9, article re3, 2005. View at Google Scholar · View at Scopus
36. P. Pitsikas, D. Lee, and A. J. Rainbow, “Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2,” Mutagenesis, vol. 22, no. 3, pp. 235–243, 2007. View at Publisher · View at Google Scholar · View at Scopus
37. L. Negureanu and F. R. Salsbury Jr., “The molecular origin of the MMR-dependent apoptosis pathway from dynamics analysis of MutSα-DNA complexes,” Journal of Biomolecular Structure & Dynamics, vol. 30, no. 3, pp. 347–361, 2012. View at Google Scholar
38. M. Iwaizumi, S. Tseng-Rogenski, and J. M. Carethers, “DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in colorectal cancer cells,” Cancer Biology and Therapy, vol. 12, no. 8, pp. 756–764, 2011. View at Google Scholar
39. P. C. Campos, V. G. Silva, C. Furtado et al., “Trypanosoma cruzi MSH2: functional analyses on different parasite strains provide evidences for a role on the oxidative stress response,” Molecular and Biochemical Parasitology, vol. 176, no. 1, pp. 8–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
40. D. H. Lee, T. R. O'Connor, and G. P. Pfeifer, “Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG→TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells,” Nucleic Acids Research, vol. 30, no. 16, pp. 3566–3573, 2002. View at Google Scholar · View at Scopus
41. S. Estes, P. C. Phillips, D. R. Denver, W. K. Thomas, and M. Lynch, “Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in caenorhabditis elegans,” Genetics, vol. 166, no. 3, pp. 1269–1279, 2004. View at Publisher · View at Google Scholar · View at Scopus
42. J. C. Conde-Pérezprina, A. Luna-López, N. E. López-Diazguerrero, P. Damián-Matsumura, A. Zentella, and M. Königsberg, “Msh2 promoter region hypermethylation as a marker of aging-related deterioration in old retired female breeder mice,” Biogerontology, vol. 9, no. 5, pp. 325–334, 2008. View at Publisher · View at Google Scholar · View at Scopus
43. I. Y. Chang, M. Jin, P. Y. Sang et al., “Senescence-dependent MutSα dysfunction attenuates mismatch repair,” Molecular Cancer Research, vol. 6, no. 6, pp. 978–989, 2008. View at Publisher · View at Google Scholar · View at Scopus
44. L. C. Young, A. C. Peters, T. Maeda et al., “DNA mismatch repair protein msh6 is required for optimal levels of ultraviolet-b-induced apoptosis in primary mouse fibroblasts,” Journal of Investigative Dermatology, vol. 121, no. 4, pp. 876–880, 2003. View at Publisher · View at Google Scholar · View at Scopus
45. S. W. L. Chan and E. H. Blackburn, “New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin,” Oncogene, vol. 21, no. 4, pp. 553–563, 2002. View at Publisher · View at Google Scholar · View at Scopus
46. M. R. Campbell, Y. Wang, S. E. Andrew, and Y. Liu, “Msh2 deficiency leads to chromosomal abnormalities, centrosome amplification, and telomere capping defect,” Oncogene, vol. 25, no. 17, pp. 2531–2536, 2006. View at Publisher · View at Google Scholar · View at Scopus
47. P. Martinez, I. Siegl-Cachedenier, J. M. Flores, and M. A. Blasco, “MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres,” Aging Cell, vol. 8, no. 1, pp. 2–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
48. A. Rizki and V. Lundblad, “Defects in mismatch repair promote telomerase-independent proliferation,” Nature, vol. 411, no. 6838, pp. 713–716, 2001. View at Publisher · View at Google Scholar · View at Scopus
49. I. Siegl-Cachedenier, P. Muñoz, J. M. Flores, P. Klatt, and M. A. Blasco, “Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres,” Genes and Development, vol. 21, no. 17, pp. 2234–2247, 2007. View at Publisher · View at Google Scholar · View at Scopus
50. I. Ibanez de Caceres, N. Frolova, R. J. Varkonyi et al., “Telomerase is frequently activated in tumors with microsatellite instability,” Cancer Biology and Therapy, vol. 3, no. 3, pp. 289–292, 2004. View at Google Scholar · View at Scopus
51. S. Perera, L. Ramyar, A. Mitri et al., “A novel complex mutation in MSH2 contributes to both Muir-Torre and Lynch Syndrome,” Journal of Human Genetics, vol. 55, no. 1, pp. 37–41, 2010. View at Publisher · View at Google Scholar · View at Scopus
52. A. Morales-Burgos, J. L. Sánchez, L. D. Figueroa et al., “MSH-2 and MLH-1 Protein expression in muir torre syndrome- related and sporadic sebaceous neoplasms,” Puerto Rico Health Sciences Journal, vol. 27, no. 4, pp. 322–327, 2008. View at Google Scholar · View at Scopus
53. D. Torre, “Multiple sebaceous tumors,” Archives of Dermatology, vol. 98, no. 5, pp. 549–551, 1968. View at Publisher · View at Google Scholar · View at Scopus
54. E. Vilar and S. B. Gruber, “Microsatellite instability in colorectal cancerthe stable evidence,” Nature Reviews Clinical Oncology, vol. 7, no. 3, pp. 153–162, 2010. View at Publisher · View at Google Scholar · View at Scopus
55. F. C. C. da Silva, M. D. Valentin, F. D. O. Ferreira, D. M. Carraro, and B. M. Rossi, “Mismatch repair genes in Lynch syndrome: a review,” Sao Paulo Medical Journal, vol. 127, no. 1, pp. 46–51, 2009. View at Google Scholar · View at Scopus
56. P. M. Lynch, “The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancer,” Surgical Oncology Clinics of North America, vol. 18, no. 4, pp. 611–624, 2009. View at Publisher · View at Google Scholar · View at Scopus
57. Y. H. Choi, M. Cotterchio, G. McKeown-Eyssen et al., “Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario,” Hereditary Cancer in Clinical Practice, vol. 7, no. 1, article 14, 2009. View at Publisher · View at Google Scholar · View at Scopus
58. O. D. K. Maddocks, A. J. Short, M. S. Donnenberg, S. Bader, and D. J. Harrison, “Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans,” PLoS ONE, vol. 4, no. 5, Article ID e5517, 2009. View at Publisher · View at Google Scholar · View at Scopus
59. G. Ponti, L. Losi, G. Pellacani et al., “Malignant melanoma in patients with hereditary nonpolyposis colorectal cancer,” British Journal of Dermatology, vol. 159, no. 1, pp. 162–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
60. S. A. Martin, A. McCarthy, L. J. Barber et al., “Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2,” EMBO Molecular Medicine, vol. 1, no. 6-7, pp. 323–337, 2009. View at Publisher · View at Google Scholar · View at Scopus
61. F. Fostira, G. Thodi, I. Konstantopoulou, R. Sandaltzopoulos, and D. Yannoukakos, “Hereditary cancer syndromes,” Journal of B.U.ON., vol. 12, no. 1, pp. S13–S22, 2007. View at Google Scholar · View at Scopus
62. A. Agarwal, S. Gupta, and R. K. Sharma, “Role of oxidative stress in female reproduction,” Reproductive Biology and Endocrinology, vol. 3, article 28, 2005. View at Publisher · View at Google Scholar · View at Scopus
63. K. Yamane, J. E. Schupp, and T. J. Kinsella, “BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage,” Cancer Research, vol. 67, no. 13, pp. 6286–6292, 2007. View at Publisher · View at Google Scholar · View at Scopus
64. R. A. Jensen, M. E. Thompson, T. L. Jetton et al., “BRCA1 is secreted and exhibits properties of a granin,” Nature Genetics, vol. 12, no. 3, pp. 303–308, 1996. View at Publisher · View at Google Scholar · View at Scopus
65. G. Neuweiler, The Biology of Bats, Oxford University Press, New York, NY, USA, 2000.
66. J. C. Conde-Pérezprina, A. Luna-López, V. Y. González-Puertos, T. Zenteno-Savín, M. A. León-Galván, and M. Königsberg, “DNA MMR systems, microsatellite instability and antioxidant activity variations in two species of wild bats: myotis velifer and Desmodus rotundus, as possible factors associated with longevity,” Age. In press.
67. G. S. Wilkinson and J. M. South, “Life history, ecology and longevity in bats,” Aging Cell, vol. 1, no. 2, pp. 124–131, 2002. View at Google Scholar · View at Scopus
68. J. H. Fitch, K. A. Shump, and A. U. Shump, “Myotis velifer,” Mammalian Species, vol. 149, pp. 1–5, 1981. View at Google Scholar
69. K. D. Jürgens and J. Prothero, “Scaling of maximal lifespan in bats,” Comparative Biochemistry and Physiology A, vol. 88, no. 2, pp. 361–367, 1987. View at Google Scholar · View at Scopus
70. R. D. Lord, F. Muradali, and L. Lazaro, “Age composition of vampire bats (Desmodus rotundus) in Northern Argentina and Southern Brazil,” Journal of Mammalogy, vol. 57, pp. 573–575, 1976. View at Google Scholar
71. A. Balmori, “El estudio de los quirópteros a través de sus emisiones ultrasónicas,” Galemys Boletín SECEM, vol. 10, pp. 12–19, 1998. View at Google Scholar
72. A. K. Brunet-Rossinni and S. N. Austad, “Ageing studies on bats: a review,” Biogerontology, vol. 5, no. 4, pp. 211–222, 2004. View at Publisher · View at Google Scholar · View at Scopus
73. T. Arai, M. Sawabe, T. Hosoi, and N. Tanaka, “Role of DNA repair systems in malignant tumor development in the elderly,” Geriatrics and Gerontology International, vol. 8, no. 2, pp. 65–72, 2008. View at Publisher · View at Google Scholar · View at Scopus
74. K. Wimmer and J. Etzler, “Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg?” Human Genetics, vol. 124, no. 2, pp. 105–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
75. S. Krüger, M. Kinzel, C. Walldorf et al., “Homozygous PMS2 germline mutations in two families with early-onset haematological malignancy, brain tumours, HNPCC-associated tumours, and signs of neurofibromatosis type 1,” European Journal of Human Genetics, vol. 16, no. 1, pp. 62–72, 2008. View at Publisher · View at Google Scholar · View at Scopus
76. N. Pabla, Z. Ma, M. A. McIlhatton, R. Fishel, and Z. Dong, “hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis,” Journal of Biological Chemistry, vol. 286, no. 12, pp. 10411–10418, 2011. View at Publisher · View at Google Scholar · View at Scopus