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Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 728547, 6 pages
Review Article

Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?

1Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Località Tappino, 86100 Campobasso, Italy
2Department of Medicine and Sugery, University of Salerno, Via Salvador Allende, 84081 Baronissi (SA), Italy
3Istituto Scientifico di Campoli/Telese, Fondazione Salvatore Maugeri, IRCCS, Via Bagni Vecchi 1, 82037 Telese Terme (BN), Italy

Received 22 June 2012; Accepted 13 August 2012

Academic Editor: William C. Burhans

Copyright © 2012 Graziamaria Corbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is a multifactorial process resulting in damage of molecules, cells, and tissues. It has been demonstrated that the expression and activity of antioxidant systems (SOD, HSPs) are modified in aging, with reduced cell ability to counteract the oxidant molecules, and consequent weak resistance to ROS accumulation. An important mechanism involved is represented by sirtuins, the activity of which is reduced by aging. Physical activity increases the expression and the activity of antioxidant enzymes, with consequent reduction of ROS. Positive effects of physical exercise in terms of antioxidant activity could be ascribable to a greater expression and activity of SOD enzymes, HSPs and SIRT1 activity. The antioxidant effects could increase, decrease, or not change in relation to the exercise protocol. Therefore, some authors by using a new approach based on the in vivo/vitro technique demonstrated that the highest survival and proliferation and the lowest senescence were obtained by performing an aerobic training. Therefore, the in vivo/vitro technique described could represent a good tool to better understand how the exercise training mediates its effects on aging-related diseases, as elderly with heart failure that represents a special population in which the exercise plays an important role in the improvement of cardiovascular function, quality of life, and survival.