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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 785743, 13 pages
http://dx.doi.org/10.1155/2012/785743
Research Article

Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Received 3 March 2012; Revised 16 May 2012; Accepted 24 May 2012

Academic Editor: Paula Ludovico

Copyright © 2012 Suzana Makpol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Jean Calleja-Agius, Mark Brincat, and Marika Borg, “Skin connective tissue and ageing,” Best Practice & Research Clinical Obstetrics & Gynaecology, 2013. View at Publisher · View at Google Scholar
  • Jing Jye Lim, Wan Zurinah Wan Ngah, Vincent Mouly, and Norwahidah Abdul Karim, “Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Vijayalakshmi Sridharan, Preeti Tripathi, Nukhet Aykin-Burns, Kimberly J Krager, Sunil K. Sharma, Eduardo G. Moros, Stepan B. Melnyk, Oleksandra Pavliv, Martin Hauer-Jensen, and Marjan Boerma, “A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure,” Radiation Research, vol. 183, no. 3, pp. 357–366, 2015. View at Publisher · View at Google Scholar
  • Weimin Ni, Yan Fang, Ling Xie, Xue Liu, Wei Shan, Ruixia Zeng, Jiansheng Liu, and Xueyuan Liu, “Adipose-Derived Mesenchymal Stem Cells Transplantation Alleviates Renal Injury in Streptozotocin-Induced Diabetic Nephropathy,” Journal Of Histochemistry & Cytochemistry, vol. 63, no. 11, pp. 842–853, 2015. View at Publisher · View at Google Scholar
  • Jaafar, Wan Ngah, Suzana Makpol, Durani, Tan, Tajul Arifin, and Mohd Yusof, “Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts,” Clinica Terapeutica, vol. 166, no. 6, pp. 365–373, 2015. View at Publisher · View at Google Scholar
  • Hong-wei Wang, Wen-peng Zhao, Jing Liu, Pan-pan Tan, Cai Zhang, and Bian-hua Zhou, “Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice,” Chemosphere, 2017. View at Publisher · View at Google Scholar
  • Nurul Alimah Abdul Nasir, Renu Agarwal, Siti Hamimah Sheikh Abdul Kadir, Sushil Vasudevan, Minaketan Tripathy, Igor Iezhitsa, Aqil Mohammad Daher, Mohd Ikraam Ibrahim, and Nafeeza Mohd Ismail, “Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats,” Plos One, vol. 12, no. 3, pp. e0174542, 2017. View at Publisher · View at Google Scholar