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Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 820285, 10 pages
Research Article

Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content

School of Biomedical Sciences and Pharmacy, The University of Newcastle and Hunter Medical Research Institute, University Drive, Newcastle, NSW 2308, Australia

Received 13 January 2012; Revised 24 January 2012; Accepted 8 February 2012

Academic Editor: Daniel Pens Gelain

Copyright © 2012 Ramatis B. de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material presents a comparison of electrophysiological properties of LC neurons treated with 100 µM Trolox that hyperpolarized and neurons that presented no changes with this treatment. Results demonstrated no changes in the analyzed parameters (excluding AP amplitude), suggesting that the hyperpolarization was an intrinsic response of this sub neuronal population.

  1. Supplementary Material