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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 854502, 8 pages
http://dx.doi.org/10.1155/2012/854502
Research Article

Overexpression of Fatty-Acid- 𝜷 -Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster

1Department of Biological Sciences, Inha University, 100 Inha-ro, Nam-gu, Incheon 402-751, Republic of Korea
2Department of Biological Sciences, Korea Advanced Institute of Science & Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea

Received 14 May 2012; Revised 23 July 2012; Accepted 3 August 2012

Academic Editor: Heinz D. Osiewacz

Copyright © 2012 Shin-Hae Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. B. Paaby and P. S. Schmidt, “Dissecting the genetics of longevity in Drosophila melanogaster,” Fly, vol. 3, no. 1, pp. 29–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Ziv and D. Hu, “Genetic variation in insulin/IGF-1 signaling pathways and longevity,” Ageing Research Reviews, vol. 10, no. 2, pp. 201–204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. C. J. Kenyon, “The genetics of ageing,” Nature, vol. 464, no. 7288, pp. 504–512, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Kapahi, D. Chen, A. N. Rogers et al., “With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging,” Cell Metabolism, vol. 11, no. 6, pp. 453–465, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Mair, I. Morantte, A. P. C. Rodrigues et al., “Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB,” Nature, vol. 470, no. 7334, pp. 404–408, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Tatar, A. Kopelman, D. Epstein, M. P. Tu, C. M. Yin, and R. S. Garofalo, “A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function,” Science, vol. 292, no. 5514, pp. 107–110, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. G. A. Walker and G. J. Lithgow, “Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals,” Aging Cell, vol. 2, no. 2, pp. 131–139, 2003. View at Google Scholar · View at Scopus
  8. C. S. Carter, M. M. Ramsey, and W. E. Sonntag, “A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan,” Trends in Genetics, vol. 18, no. 6, pp. 295–301, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Klöting and M. Blüher, “Extended longevity and insulin signaling in adipose tissue,” Experimental Gerontology, vol. 40, no. 11, pp. 878–883, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Kaletsky and C. T. Murphy, “The role of insulin/IGF-like signaling in C. elegans longevity and aging,” DMM Disease Models and Mechanisms, vol. 3, no. 7-8, pp. 415–419, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Salminen and K. Kaarniranta, “Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-κB signaling,” Cellular Signalling, vol. 22, no. 4, pp. 573–577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Rizki, T. N. Iwata, J. Li et al., “The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO,” PLoS Genetics, vol. 7, no. 9, Article ID e1002235, 2011. View at Google Scholar
  13. M. Tatar, “Diet restriction in Drosophila melanogaster: design and analysis,” Interdisciplinary Topics in Gerontology, vol. 35, pp. 115–136, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. D. M. O'Brien, K. J. Min, T. Larsen, and M. Tatar, “Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan,” Current Biology, vol. 18, no. 4, pp. R155–R156, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. J. Min, R. Yamamoto, S. Buch, M. Pankratz, and M. Tatar, “Drosophila lifespan control by dietary restriction independent of insulin-like signaling,” Aging Cell, vol. 7, no. 2, pp. 199–206, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. J. V. Smith, L. K. Heilbronn, and E. Ravussin, “Energy restriction and aging,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 7, no. 6, pp. 615–622, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Gáliková, P. Klepsatel, G. Senti, and T. Flatt, “Steroid hormone regulation of C. elegans and Drosophila aging and life history,” Experimental Gerontology, vol. 46, no. 2-3, pp. 141–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Broué, P. Liere, C. Kenyon, and E. E. Baulieu, “A steroid hormone that extends the lifespan of Caenorhabditis elegans,” Aging Cell, vol. 6, no. 1, pp. 87–94, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Paik, Y. G. Jang, Y. E. Lee et al., “Misexpression screen delineates novel genes controlling Drosophila lifespan,” Mechanisms of Ageing and Development, vol. 133, no. 5, pp. 234–245, 2012. View at Google Scholar
  20. D. G. Hardie and D. A. Pan, “Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase,” Biochemical Society Transactions, vol. 30, no. 6, pp. 1064–1070, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. M. D. Bruss, C. F. Khambatta, M. A. Ruby, I. Aggarwal, and M. K. Hellerstein, “Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates,” American Journal of Physiology, vol. 298, no. 1, pp. E108–E116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Xu, P. Gopalacharyulu, T. Seppanen- et al., “Insulin signaling regulates fatty acid catabolism at the level of CoA activation,” PLoS Genetics, vol. 8, no. 1, Article ID e1002478, 2012. View at Google Scholar
  23. J. E. Zimmerman, M. T. Chan, N. Jackson, G. Maislin, and A. I. Pack, “Genetic background has a major impact on differences in sleep resulting from environmental influences in Drosophila,” Sleep, vol. 35, pp. 545–557, 2012. View at Google Scholar
  24. J. H. Veerkamp and R. G. H. J. Maatman, “Cytoplasmic fatty acid-binding proteins: their structure and genes,” Progress in Lipid Research, vol. 34, no. 1, pp. 17–52, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. U. Janssen and W. Stoffel, “Disruption of mitochondrial β-oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse,” Journal of Biological Chemistry, vol. 277, no. 22, pp. 19579–19584, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. S. M. Houten and R. J. A. Wanders, “A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation,” Journal of Inherited Metabolic Disease, vol. 33, no. 5, pp. 469–477, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Roman, K. Endo, L. Zong, and R. L. Davis, “P[switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 22, pp. 12602–12607, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. M. D. W. Piper and A. Bartke, “Diet and aging,” Cell Metabolism, vol. 8, no. 2, pp. 99–104, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Ristow and S. Schmeisser, “Extending life span by increasing oxidative stress,” Free Radical Biology and Medicine, vol. 51, no. 2, pp. 327–336, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. B. P. Yu and H. Y. Chung, “Stress resistance by caloric restriction for longevity,” Annals of the New York Academy of Sciences, vol. 928, pp. 39–47, 2001. View at Google Scholar · View at Scopus
  31. S. J. Broughton, M. D. W. Piper, T. Ikeya et al., “Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 8, pp. 3105–3110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. K. S. Lee, K. Iijima-Ando, K. Iijima et al., “JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span,” Journal of Biological Chemistry, vol. 284, no. 43, pp. 29454–29461, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. E. L. Greer, M. R. Banko, and A. Brunet, “AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity,” Annals of the New York Academy of Sciences, vol. 1170, pp. 688–692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. M. K. Lehtinen, Z. Yuan, P. R. Boag et al., “A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span,” Cell, vol. 125, no. 5, pp. 987–1001, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. T. B. Dansen, L. M. M. Smits, M. H. Van Triest et al., “Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity,” Nature Chemical Biology, vol. 5, no. 9, pp. 664–672, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. D. H. Kim, J. Y. Kim, B. P. Yu, and H. Y. Chung, “The activation of NF-κB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction,” Biogerontology, vol. 9, no. 1, pp. 33–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. D. S. Hwangbo, B. Gershman, M. P. Tu, M. Palmer, and M. Tatar, “Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body,” Nature, vol. 429, no. 6991, pp. 562–566, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. M. E. Giannakou, M. Goss, J. Jacobson, G. Vinti, S. J. Leevers, and L. Partridge, “Dynamics of the action of dFOXO on adult mortality in Drosophila,” Aging Cell, vol. 6, no. 4, pp. 429–438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Mourikis, G. D. Hurlbut, and S. Artavanis-Tsakonas, “Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 5, pp. 1307–1312, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. B. R. Strub, T. L. Parkes, S. T. Mukai et al., “Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene,” Genome, vol. 51, no. 6, pp. 409–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. Kishita, M. Tsuda, and T. Aigaki, “Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency,” Biochemical and Biophysical Research Communications, vol. 419, pp. 344–349, 2012. View at Google Scholar
  42. J. R. Gerstner, W. M. Vanderheyden, P. J. Shaw, C. F. Landry, and J. C. Yin, “Cytoplasmic to nuclear localization of fatty-acid binding protein correlates with specific forms of long-term memory in Drosophila,” Communicative & Integrative Biology, vol. 4, pp. 623–626, 2011. View at Google Scholar
  43. M. Matsumoto, S. Han, T. Kitamura, and D. Accili, “Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism,” Journal of Clinical Investigation, vol. 116, no. 9, pp. 2464–2472, 2006. View at Publisher · View at Google Scholar · View at Scopus