Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 485201, 10 pages
http://dx.doi.org/10.1155/2013/485201
Research Article

Dietary Flavonoids as Therapeutics for Preterm Birth: Luteolin and Kaempferol Suppress Inflammation in Human Gestational Tissues In Vitro

Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Melbourne, VIC 3084, Australia

Received 19 April 2013; Accepted 20 May 2013

Academic Editor: Tullia Maraldi

Copyright © 2013 Courtney Wall et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. March of Dimes PfM, Newborn and Child Health, Save the Children, WHO. Born Too Soon: The Global Action Report on Preterm Birth, C. P. Howson, M. V. Kinney, and J. E. Lawn, Eds., World Health Organization, Geneva, Switzerland, 2012.
  2. R. L. Goldenberg, J. F. Culhane, J. D. Iams, and R. Romero, “Epidemiology and causes of preterm birth,” The Lancet, vol. 371, no. 9606, pp. 75–84, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Laws and E. A. Sullivan, Australia's Mothers and Babies 2007, Perinatal Statistics Series, Australian Institute of Health and Welfare, Canberra, Australia, 2009.
  4. Birth CoUP, Assuring Healthy Outcomes, Preterm Birth: Causes, Consequences, and Prevention, The National Academies Press, 2007.
  5. R. Menon, A. L. Dunlop, M. R. Kramer, S. J. Fortunato, and C. J. Hogue, “An overview of racial disparities in preterm birth rates: caused by infection or inflammatory response?” Acta Obstetricia et Gynecologica Scandinavica, vol. 90, no. 12, pp. 1325–1331, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Lappas and G. E. Rice, “The role and regulation of the nuclear factor κ B signalling pathway in human labour,” Placenta, vol. 28, no. 5-6, pp. 543–556, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Lappas and G. E. Rice, “Transcriptional regulation of the processes of human labour and delivery,” Placenta, vol. 30, pp. 90–95, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. R. Mohan, S. R. Sooranna, T. M. Lindstrom, M. R. Johnson, and P. R. Bennett, “The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-κB activity in human amnion cells,” Endocrinology, vol. 148, no. 4, pp. 1850–1857, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Khanjani, V. Terzidou, M. R. Johnson, and P. R. Bennett, “NFκB and AP-1 drive human myometrial IL8 expression,” Mediators of Inflammation, vol. 2012, Article ID 504952, 8 pages, 2012. View at Publisher · View at Google Scholar
  10. B. H. Havsteen, “The biochemistry and medical significance of the flavonoids,” Pharmacology and Therapeutics, vol. 96, no. 2-3, pp. 67–202, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Middleton Jr., C. Kandaswami, and T. C. Theoharides, “The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,” Pharmacological Reviews, vol. 52, no. 4, pp. 673–751, 2000. View at Google Scholar · View at Scopus
  12. L. H. Lv, Y. B. Zhang, and Q. H. Kong, “Luteolin prevents LPS-induced TNF-α expression in cardiac myocytes through inhibiting NF-κB signaling pathway,” Inflammation, vol. 34, no. 6, pp. 620–629, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S.-H. Kim, K.-J. Shin, D. Kim et al., “Luteolin inhibits the nuclear factor-κB transcriptional activity in Rat-1 fibroblasts,” Biochemical Pharmacology, vol. 66, no. 6, pp. 955–963, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-C. Chen, M.-P. Chow, W.-C. Huang, Y.-C. Lin, and Y.-J. Chang, “Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships,” Molecular Pharmacology, vol. 66, no. 3, pp. 683–693, 2004. View at Google Scholar · View at Scopus
  15. V. García-Mediavilla, I. Crespo, P. S. Collado et al., “The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor κB pathway in Chang Liver cells,” European Journal of Pharmacology, vol. 557, no. 2-3, pp. 221–229, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. C.-Y. Chen, W.-H. Peng, K.-D. Tsai, and S.-L. Hsu, “Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages,” Life Sciences, vol. 81, no. 23-24, pp. 1602–1614, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. E. M. Choi and Y. S. Lee, “Luteolin suppresses IL-1β-induced cytokines and MMPs production via p38 MAPK, JNK, NF-κB and AP-1 activation in human synovial sarcoma cell line, SW982,” Food and Chemical Toxicology, vol. 48, no. 10, pp. 2607–2611, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Y. Lim, H. J. Cho, J. Kim, C. W. Nho, K. W. Lee, and J. H. Y. Park, “Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells,” BMC Gastroenterology, vol. 12, article 9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Deqiu, L. Kang, Y. Jiali, L. Baolin, and L. Gaolin, “Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium,” Biochimie, vol. 93, no. 3, pp. 506–512, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. B. M. Markaverich, M. Vijjeswarapu, K. Shoulars, and M. Rodriguez, “Luteolin and gefitinib regulation of EGF signaling pathway and cell cycle pathway genes in PC-3 human prostate cancer cells,” Journal of Steroid Biochemistry and Molecular Biology, vol. 122, no. 4, pp. 219–231, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Zhang and D. Liu, “Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function,” European Journal of Pharmacology, vol. 670, no. 1, pp. 325–332, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhang, A. Y. Chen, M. Li, C. Chen, and Q. Yao, “Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells,” Journal of Surgical Research, vol. 148, no. 1, pp. 17–23, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M.-K. Lin, Y.-L. Yu, K.-C. Chen et al., “Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells,” Immunobiology, vol. 216, no. 10, pp. 1103–1109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. R. Bennett, M. P. Rose, L. Myatt, and M. G. Elder, “Preterm labor: stimulation of arachidonic acid metabolism in human amnion cells by bacterial products,” American Journal of Obstetrics and Gynecology, vol. 156, no. 3, pp. 649–655, 1987. View at Google Scholar · View at Scopus
  25. M. Lappas, M. Permezel, H. M. Georgiou, and G. E. Rice, “Nuclear factor κ B regulation of proinflammatory cytokines in human gestational tissues in vitro,” Biology of Reproduction, vol. 67, no. 2, pp. 668–673, 2002. View at Google Scholar · View at Scopus
  26. M. Lappas, M. Permezel, H. M. Georgiou, and G. E. Rice, “Regulation of Phospholipase Isozymes by Nuclear Factor-κB in Human Gestational Tissues in Vitro,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 5, pp. 2365–2372, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Lappas, M. Permezel, and G. E. Rice, “N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-κB deoxyribonucleic acid-binding activity in human fetal membranes in Vitro,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1723–1729, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Lappas, M. Permezel, and G. E. Rice, “15-Deoxy-Δ12,14-Prostaglandin J2 and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues,” Placenta, vol. 27, no. 11-12, pp. 1060–1072, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Lappas, T. L. Odumetse, C. Riley et al., “Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-κB signalling pathways,” Placenta, vol. 29, no. 12, pp. 995–1002, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. T. M. Lindström and P. R. Bennett, “15-Deoxy-δ12,14-prostaglandin J2 inhibits interleukin-1β-induced nuclear factor-κB in human amnion and myometrial cells: mechanisms and implications,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3534–3543, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Lanoix, J. St-Pierre, A.-A. Lacasse, M. Viau, J. Lafond, and C. Vaillancourt, “Stability of reference proteins in human placenta: general protein stains are the benchmark,” Placenta, vol. 33, no. 3, pp. 151–156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. D. C. Scherer, J. A. Brockman, Z. Chen, T. Maniatis, and D. W. Ballard, “Signal-induced degradation of IκBα requires site-specific ubiquitination,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 24, pp. 11259–11263, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Udou, T. Hachisuga, H. Tsujioka, and T. Kawarabayashi, “The role of c-jun protein in proliferation and apoptosis of the endometrium throughout the menstrual cycle,” Gynecologic and Obstetric Investigation, vol. 57, no. 3, pp. 121–126, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Steinborn, M. Geisse, and M. Kaufmann, “Expression of cytokine receptors in the placenta in term and preterm labour,” Placenta, vol. 19, no. 2-3, pp. 165–170, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Steinborn, H. Günes, S. Röddiger, and E. Halberstadt, “Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection,” Obstetrics and Gynecology, vol. 88, no. 4, pp. 534–539, 1996. View at Publisher · View at Google Scholar · View at Scopus
  37. L. F. Gonçalves, T. Chaiworapongsa, and R. Romero, “Intrauterine infection and prematurity,” Mental Retardation and Developmental Disabilities Research Reviews, vol. 8, no. 1, pp. 3–13, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Romero, M. Mazor, H. Munoz, R. Gomez, M. Galasso, and D. M. Sherer, “The preterm labor syndrome,” Annals of the New York Academy of Sciences, vol. 734, pp. 414–429, 1994. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Y. Lee, I. A. Buhimschi, A. T. Dulay et al., “IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes,” Journal of Immunology, vol. 186, no. 5, pp. 3226–3236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. M. B. Sennström, G. Ekman, G. Westergren-Thorsson et al., “Human cervical ripening, an inflammatory process mediated by cytokines,” Molecular Human Reproduction, vol. 6, no. 4, pp. 375–381, 2000. View at Google Scholar · View at Scopus
  41. P. R. Bennett, M. G. Elder, and L. Myatt, “The effects of lipoxygenase metabolites of arachidonic acid on human myometrial contractility,” Prostaglandins, vol. 33, no. 6, pp. 837–844, 1987. View at Google Scholar · View at Scopus
  42. J. M. Calderón-Montaño, E. Burgos-Morón, C. Pérez-Guerrero, and M. López-Lázaro, “A review on the dietary flavonoid kaempferol,” Mini-Reviews in Medicinal Chemistry, vol. 11, no. 4, pp. 298–344, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. M. López-Lázaro, “Distribution and biological activities of the flavonoid luteolin,” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 1, pp. 31–59, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. C.-R. Roh, W.-J. Oh, B.-K. Yoon, and J.-H. Lee, “Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells,” Molecular Human Reproduction, vol. 6, no. 1, pp. 96–102, 2000. View at Google Scholar · View at Scopus
  45. M. N. Bou-Resli, N. S. Al-Zaid, and M. E. A. Ibrahim, “Full-term and prematurely ruptured fetal membranes. An ultrastructural study,” Cell and Tissue Research, vol. 220, no. 2, pp. 263–278, 1981. View at Google Scholar · View at Scopus
  46. H. Yang, Q. Liu, J. H. Ahn et al., “Luteolin downregulates IL-1β-induced MMP-9 and-13 expressions in osteoblasts via inhibition of ERK signalling pathway,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 27, no. 2, pp. 261–266, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. S. C. Shen, C. W. Lin, H. M. Lee, L. L. Chien, and Y. C. Chen, “Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: differential inhibitory effects of flavonoids,” Neuroscience, vol. 140, no. 2, pp. 477–489, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. V. C. Allport, D. M. Slater, R. Newton, and P. R. Bennett, “NF-κB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH),” Molecular Human Reproduction, vol. 6, no. 6, pp. 561–565, 2000. View at Google Scholar · View at Scopus
  49. G. Pirianov, S. N. Waddington, T. M. Lindström, V. Terzidou, H. Mehmet, and P. R. Bennett, “The cyclopentenone 15-deoxy-δ12,14-prostaglandin J 2 delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse,” Endocrinology, vol. 150, no. 2, pp. 699–706, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. C. A. Nath, C. V. Ananth, J. C. Smulian, and M. R. Peltier, “Can sulfasalazine prevent infection-mediated pre-term birth in a murine model?” American Journal of Reproductive Immunology, vol. 63, no. 2, pp. 144–149, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. S. C. Gupta, J. H. Kim, S. Prasad, and B. B. Aggarwal, “Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals,” Cancer and Metastasis Reviews, vol. 29, no. 3, pp. 405–434, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. G. G. Duthie, P. T. Gardner, and J. A. M. Kyle, “Plant polyphenols: are they the new magic bullet?” Proceedings of the Nutrition Society, vol. 62, no. 3, pp. 599–603, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. J. R. Johnson, E. Makaji, S. Ho, B. Xiong, D. J. Crankshaw, and A. C. Holloway, “Effect of maternal raspberry leaf consumption in rats on pregnancy outcome and the fertility of the female offspring,” Reproductive Sciences, vol. 16, no. 6, pp. 605–609, 2009. View at Publisher · View at Google Scholar · View at Scopus