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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 802734, 11 pages
http://dx.doi.org/10.1155/2013/802734
Research Article

Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue

1Department of Zoology and Invertebrate Ecology, Laboratory of Physiology and Animal Biochemistry, The John Paul II Catholic University of Lublin, 102 Kraśnicka Avenue, 20-718 Lublin, Poland
2Centre of Interdisciplinary Research, Laboratory of Oxidative Stress, The John Paul II Catholic University of Lublin, 102 Kraśnicka Avenue, 20-718 Lublin, Poland

Received 3 February 2013; Revised 7 April 2013; Accepted 8 April 2013

Academic Editor: Kota V. Ramana

Copyright © 2013 Agnieszka Ścibior et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125  /mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06  /mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the -independent action and its antagonistic interaction with . The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of or exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed -stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of with and and from the antagonistic interactions of with and . The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver.