Oxidative Medicine and Cellular Longevity

Review Article

Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury

Table 2

The biological characteristics of H2S-releasing hybrid drugs.
CompoundsParent drugsTherapeutic effectsReferences
ACS2Valproic acidAnticancer[116]
Antiangiogenesis[117]
ACS6SildenafilProerectile[118]
Neuroprotection[119]
Protection against oxidative stress[120]
ACS14AspirinProtection against oxidative stress[121]
Prevent the progression of atherosclerosis[122]
Antiaggregatory[123]
Protection against I/R injury[124]
Modulation of thiol homeostasis[125]
Neuroprotection[115]
ACS15*DiclofenacAnticancer[126]
Antiosteolysis[127]
Anti-inflammation[128]
Antiangiogenesis[117]
ACS18SulindacAnticancer[126]
Antiangiogenesis[117]
ACS21Salicylic acidProtection against I/R injury[124]
ACS32DiclofenacAntiosteolysis[127]
ACS33Valproic acidAnticancer[129]
Inhibition of histone deacetylase activity[129]
ACS67LatanoprostRegulation of insulin secretion[114]
Neuroprotection[85]
ACS83L-DOPAAnti-inflammation[130]
ACS84L-DOPAAnti-inflammation[131]
Neuroprotection[132]
ACS85L-DOPAAnti-inflammation[118]
ACS86L-DOPAAnti-inflammation[118]
ATB-284UnknownPrevention against irritable bowel syndrome[133]
ATB-337*DiclofenacAnti-inflammation[134]
ATB-343IndomethacinAnti-inflammation[135]
ATB-345NaproxenAnti-inflammation[136]
ATB-346NaproxenAnti-inflammation[136]
Anticancer[137]
ATB-429MesalamineAnti-inflammation[138]
Abirritation[139]
HS-aspirin (HS-ASA)AspirinAnticancer[140]
Compound 8e3-n-ButylphthalideAntithrombosis[141]
H2S-EXP 3174Active metabolite of losartanVasorelaxation[142]
NOSH-aspirin (NBS-1120)AspirinAnticancer[143]
Anti-inflammation[144]
NOSH-naproxen (AVT-219)NaproxenAnti-inflammation[145]
NOSH-sulindac (AVT-18A)SulindacAnti-inflammation[145]
S-diclofenac*DiclofenacAnti-inflammation [146]
Protection against I/R injury[146]
S-zofenoprilZofenoprilImprovement of vascular function[147]
These compounds are remarkably similar to each other.