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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 392169, 14 pages
Review Article

Resveratrol: A Focus on Several Neurodegenerative Diseases

1Department of Chemical Sciences, University of Messina, V. le Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
2Biochemistry and Clinical Biochemistry Institute, School of Medicine, Catholic University, L. go F. Vito n.1, 00168 Rome, Italy
3C.N.R. Institute of Chemistry of Molecular Recognition, L. go F. Vito n.1, 00168 Rome, Italy

Received 26 September 2014; Revised 19 December 2014; Accepted 26 December 2014

Academic Editor: David Vauzour

Copyright © 2015 Ester Tellone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson’s, Alzheimer’s, and Huntington’s diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.