Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression

Figure 2

The histological assessment using cresyl violet staining after ischemic injury. Atlas of rat brain mainly presents the corpus callosum, cerebral cortex (a), and striatum (b). Cresyl violet staining indicated that considerable cell loss was observed in the 24 hr MCAO group whereas more healthy cell bodies in striatum and cortex were observed in MCAO with GSH treatment group. Each assessment included 5 repeats per animal. (a) Cortex, (b) striatum, scale bar: 200 μm, NC: normal control group, EC: experimental control, reperfusion 24 hr after MCAO injury group, and GSH: GSH treatment and reperfusion 24 hr after MCAO injury group.