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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 636410, 8 pages
Research Article

An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

1Department of Pathophysiology, Harbin Medical University, Harbin 150081, China
2Department of Pathology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
3Department of Pathophysiology, Qiqihar Medical College, Qiqihar 161006, China
4Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Harbin Medical University, Harbin 150081, China
5Department of Oncology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China
6Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1

Received 19 November 2014; Revised 9 January 2015; Accepted 9 January 2015

Academic Editor: Steven S. An

Copyright © 2015 Li Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H2S is thus indicated.