Oxidative Medicine and Cellular Longevity

Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development


Publishing date
20 Mar 2015
Status
Published
Submission deadline
30 Nov 2014

Lead Editor

1Lakehead University, Thunder Bay, Canada

2Johns Hopkins University, Baltimore, USA

3Nanjing Medical University, Nanjing, China

4Harbin Medical University, Harbin, China

5Shanxi University, Taiyuan, China


Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development

Description

Hydrogen sulfide (H 2S) has emerged to be one important member of the family of gasotransmitters, together with nitric oxide and carbon monoxide. The ubiquitous distribution of H 2S-producing enzymes and the potent chemical reactivities of H 2S in biological system make this molecule unique in regulating cellular and organ functions in both health and diseases. H 2S-induced S-sulfhydration of its targeted proteins is a novel and important signaling mechanism involving the posttranslational modification of proteins. Pathophysiological abnormalities, related to altered H 2S metabolism and function, have been demonstrated in many diseases. H 2S also possesses a great therapeutic potential in age-associated diseases by modulation of oxidative stress. The correlation of H 2S metabolism with physiological and pathophysiological changes that contribute to redox homeostasis and aging has been largely unknown.

We invite investigators to submit original research articles as well as review articles highlighting the novel discoveries and recent progress in relation to H 2S signaling in redox homeostasis, inflammation, cellular energetics, cell growth and apoptosis, interaction with other gasotransmitters, protein and DNA modification, age-related disorders, and so on. The articles that dissect the multitude of H 2S effects at the molecular, cellular, and system levels in humans and various animal disease models are especially welcomed.

Potential topics include, but are not limited to:

  • H 2S signaling in oxidative stress
  • H 2S signaling in cellular senescence and aging development
  • S-sulfhydration regulation of proteins
  • Recent advance on the analytical methods for detection of endogenous H 2S
  • Current strategies to regulate H 2S-producing enzyme and alter H 2S production
  • Development of new H 2S donors and H 2S probes
  • Roles of H 2S in mitochondrial functions
  • Pathological implication of H 2S in humans and animal disease models

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 357824
  • - Editorial

Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development

Guangdong Yang | Steven S. An | ... | Yanxi Pei
  • Special Issue
  • - Volume 2015
  • - Article ID 186908
  • - Review Article

Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury

Dongdong Wu | Jun Wang | ... | Yanzhang Li
  • Special Issue
  • - Volume 2015
  • - Article ID 458720
  • - Review Article

Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?

Kai Song | Qian Li | ... | Li-Fang Hu
  • Special Issue
  • - Volume 2015
  • - Article ID 397502
  • - Review Article

Physiological Implications of Hydrogen Sulfide in Plants: Pleasant Exploration behind Its Unpleasant Odour

Zhuping Jin | Yanxi Pei
  • Special Issue
  • - Volume 2015
  • - Article ID 754670
  • - Research Article

Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt

Yanfang Zong | Yaqian Huang | ... | Hongfang Jin
  • Special Issue
  • - Volume 2015
  • - Article ID 593407
  • - Review Article

Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis

Shufang Zhang | Chuli Pan | ... | Gensheng Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 758358
  • - Research Article

Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice

Sheng Jin | Shi-Xin Pu | ... | Yi-Chun Zhu
  • Special Issue
  • - Volume 2015
  • - Article ID 804603
  • - Research Article

Hydrogen Sulfide Alleviates Cadmium-Induced Cell Death through Restraining ROS Accumulation in Roots of Brassica rapa L. ssp. pekinensis

Liping Zhang | Yanxi Pei | ... | Yanjie Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 976848
  • - Research Article

Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel

Qiushi Wang | Binlin Song | ... | He-Ping Ma
  • Special Issue
  • - Volume 2015
  • - Article ID 636410
  • - Research Article

An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

Li Zhang | Qi Qi | ... | Rui Wang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate49%
Submission to final decision75 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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