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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 732302, 14 pages
http://dx.doi.org/10.1155/2015/732302
Review Article

Biomarkers of Dietary Polyphenols in Cancer Studies: Current Evidence and Beyond

Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, USA

Received 26 September 2014; Accepted 6 January 2015

Academic Editor: Tullia Maraldi

Copyright © 2015 Jincheng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Scalbert, C. Manach, C. Morand, C. Rémésy, and L. Jiménez, “Dietary polyphenols and the prevention of diseases,” Critical Reviews in Food Science and Nutrition, vol. 45, no. 4, pp. 287–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Scalbert, I. T. Johnson, and M. Saltmarsh, “Polyphenols: antioxidants and beyond,” The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 215S–217S, 2005. View at Google Scholar · View at Scopus
  3. J. M. Landete, “Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health,” Critical Reviews in Food Science and Nutrition, vol. 52, no. 10, pp. 936–948, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. I. C. W. Arts and P. C. H. Hollman, “Polyphenols and disease risk in epidemiologic studies,” The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 317S–325S, 2005. View at Google Scholar · View at Scopus
  5. F. Visioli, C. A. de la Lastra, C. Andres-Lacueva et al., “Polyphenols and human health: a prospectus,” Critical Reviews in Food Science and Nutrition, vol. 51, no. 6, pp. 524–546, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J.-S. Wang, H. Luo, P. Wang et al., “Validation of green tea polyphenol biomarkers in a phase II human intervention trial,” Food and Chemical Toxicology, vol. 46, no. 1, pp. 232–240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. C.-L. Shen, M.-C. Chyu, and J.-S. Wang, “Tea and bone health: steps forward in translational nutrition,” The American Journal of Clinical Nutrition, vol. 98, no. 6, pp. 1694S–1699S, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. C. L. Shen, M. C. Chyu, J. K. Yeh et al., “Effect of green tea polyphenols and Tai Chi exercise on bone health in postmenopausal women with low bone mass: a 24-week placebo-controlled randomized trial,” The FASEB Journal, vol. 25, p. 594.3, 2011. View at Google Scholar
  9. O. I. Parisi, F. Puoci, and D. Restuccia, “Polyphenols and their formulations: different strategies to overcome the drawbacks associated with their poor stability and bioavailability,” in Polyphenols in Human Health and Disease, R. R. Watson, V. R. Preedy, and S. Zibadi, Eds., chapter 4, pp. 29–45, Academic Press, San Diego, Calif, USA, 2014. View at Google Scholar
  10. A. Scalbert and G. Williamson, “Dietary intake and bioavailability of polyphenols,” Journal of Nutrition, vol. 130, no. 8, supplement, pp. 2073S–2085S, 2000. View at Google Scholar · View at Scopus
  11. P. A. Kroon, M. N. Clifford, A. Crozier et al., “How should we assess the effects of exposure to dietary polyphenols in vitro?” The American Journal of Clinical Nutrition, vol. 80, no. 1, pp. 15–21, 2004. View at Google Scholar · View at Scopus
  12. K. D. R. Setchell, N. M. Brown, L. Zimmer-Nechemias et al., “Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability,” The American Journal of Clinical Nutrition, vol. 76, no. 2, pp. 447–453, 2002. View at Google Scholar · View at Scopus
  13. C. S. Yang, L. Chen, M. J. Lee, D. Balentine, M. C. Kuo, and S. P. Schantz, “Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers,” Cancer Epidemiology Biomarkers & Prevention, vol. 7, no. 4, pp. 351–354, 1998. View at Google Scholar · View at Scopus
  14. J. Linseisen and S. Rohrmann, “Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet-cancer relationship in humans,” European Journal of Nutrition, vol. 47, supplement 2, pp. 60–68, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Kipnis, A. F. Subar, D. Midthune et al., “Structure of dietary measurement error: results of the OPEN Biomarker Study,” American Journal of Epidemiology, vol. 158, no. 1, pp. 14–21, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Nagata, T. Mizoue, K. Tanaka et al., “Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population,” Japanese Journal of Clinical Oncology, vol. 44, no. 3, pp. 282–295, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. H. D. Woo and J. Kim, “Dietary flavonoid intake and risk of stomach and colorectal cancer,” World Journal of Gastroenterology, vol. 19, no. 7, pp. 1011–1019, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H. D. Woo and J. Kim, “Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis,” PLoS ONE, vol. 8, no. 9, Article ID e75604, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Malerba, C. Galeone, C. Pelucchi et al., “A meta-analysis of coffee and tea consumption and the risk of glioma in adults,” Cancer Causes and Control, vol. 24, no. 2, pp. 267–276, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. Z.-H. Hu, Y.-W. Lin, X. Xu et al., “No association between tea consumption and risk of renal cell carcinoma: a meta-analysis of epidemiological studies,” Asian Pacific Journal of Cancer Prevention, vol. 14, no. 3, pp. 1691–1695, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Hui, X. Qi, Z. Qianyong, P. Xiaoli, Z. Jundong, and M. Mantian, “Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies,” PLoS ONE, vol. 8, no. 1, Article ID e54318, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. Z.-H. Wang, Q.-Y. Gao, and J.-Y. Fang, “Green tea and incidence of colorectal cancer: evidence from prospective cohort studies,” Nutrition and Cancer, vol. 64, no. 8, pp. 1143–1152, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. G. M. Braem, N. C. Onland-Moret, L. J. Schouten et al., “Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis,” The American Journal of Clinical Nutrition, vol. 95, no. 5, pp. 1172–1181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. N.-P. Tang, H. Li, Y.-L. Qiu, G.-M. Zhou, and J. Ma, “Tea consumption and risk of endometrial cancer: a metaanalysis,” American Journal of Obstetrics and Gynecology, vol. 201, no. 6, pp. 605.e1–605.e8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy, “Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies,” The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 230S–242S, 2005. View at Google Scholar · View at Scopus
  26. J. Kühnau, “The flavonoids. A class of semi-essential food components: their role in human nutrition,” World Review of Nutrition and Dietetics, vol. 24, pp. 117–191, 1976. View at Google Scholar · View at Scopus
  27. M.-L. Ovaskainen, R. Törrönen, J. M. Koponen et al., “Dietary intake and major food sources of polyphenols in Finnish adults,” Journal of Nutrition, vol. 138, no. 3, pp. 562–566, 2008. View at Google Scholar · View at Scopus
  28. J. Pérez-Jiménez, L. Fezeu, M. Touvier et al., “Dietary intake of 337 polyphenols in French adults,” The American Journal of Clinical Nutrition, vol. 93, no. 6, pp. 1220–1228, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Zamora-Ros, C. Andres-Lacueva, R. M. Lamuela-Raventós et al., “Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain),” Journal of the American Dietetic Association, vol. 110, no. 3, pp. 390–398, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. X. Wu, G. R. Beecher, J. M. Holden, D. B. Haytowitz, S. E. Gebhardt, and R. L. Prior, “Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption,” Journal of Agricultural and Food Chemistry, vol. 54, no. 11, pp. 4069–4075, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Mazza and C. D. Kay, “Bioactivity, absorption, and metabolism of anthocyanins,” in Recent Advances in Polyphenol Research, pp. 228–262, Wiley-Blackwell, 2009. View at Google Scholar
  32. I. Fernandes, A. Faria, C. Calhau, V. de Freitas, and N. Mateus, “Bioavailability of anthocyanins and derivatives,” Journal of Functional Foods, vol. 7, no. 1, pp. 54–66, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. T. K. McGhie and M. C. Walton, “The bioavailability and absorption of anthocyanins: towards a better understanding,” Molecular Nutrition and Food Research, vol. 51, no. 6, pp. 702–713, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. R. M. de Ferrars, C. Czank, Q. Zhang et al., “The pharmacokinetics of anthocyanins and their metabolites in humans,” British Journal of Pharmacology, vol. 171, no. 13, pp. 3268–3282, 2014. View at Publisher · View at Google Scholar
  35. D. Ingram, K. Sanders, M. Kolybaba, and D. Lopez, “Case-control study of phyto-oestrogens and breast cancer,” The Lancet, vol. 350, no. 9083, pp. 990–994, 1997. View at Publisher · View at Google Scholar · View at Scopus
  36. I. den Tonkelaar, L. Keinan-Boker, P. V. Veer et al., “Urinary phytoestrogens and postmenopausal breast cancer risk,” Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 3, pp. 223–228, 2001. View at Google Scholar · View at Scopus
  37. R. Piller, J. Chang-Claude, and J. Linseisen, “Plasma enterolactone and genistein and the risk of premenopausal breast cancer,” European Journal of Cancer Prevention, vol. 15, no. 3, pp. 225–232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Verheus, C. H. van Gils, L. Keinan-Boker, P. B. Grace, S. A. Bingham, and P. H. M. Peeters, “Plasma phytoestrogens and subsequent breast cancer risk,” Journal of Clinical Oncology, vol. 25, no. 6, pp. 648–655, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. P. B. Grace, J. I. Taylor, Y.-L. Low et al., “Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European Prospective Investigation of Cancer and Nutrition-Norfolk,” Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 5, pp. 698–708, 2004. View at Google Scholar · View at Scopus
  40. W. Zheng, Q. Dai, L. J. Custer et al., “Urinary excretion of isoflavonoids and the risk of breast cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 8, no. 1, pp. 35–40, 1999. View at Google Scholar · View at Scopus
  41. Q. Dai, A. A. Franke, F. Jin et al., “Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 9, pp. 815–821, 2002. View at Google Scholar · View at Scopus
  42. M. Iwasaki, M. Inoue, T. Otani et al., “Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan public health center-based prospective study group,” Journal of Clinical Oncology, vol. 26, no. 10, pp. 1677–1683, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Kurahashi, M. Iwasaki, M. Inoue, S. Sasazuki, and S. Tsugane, “Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center,” Journal of Clinical Oncology, vol. 26, no. 36, pp. 5923–5929, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Ward, G. Chapelais, G. G. C. Kuhnle, R. Luben, K.-T. Khaw, and S. Bingham, “Lack of prospective associations between plasma and urinary phytoestrogens and risk of prostate or colorectal cancer in the European Prospective into Cancer-Norfolk study,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 10, pp. 2891–2894, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. R. C. Travis, E. A. Spencer, N. E. Allen et al., “Plasma phyto-oestrogens and prostate cancer in the European Prospective Investigation into Cancer and Nutrition,” British Journal of Cancer, vol. 100, no. 11, pp. 1817–1823, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. S.-Y. Park, L. R. Wilkens, A. A. Franke et al., “Urinary phytoestrogen excretion and prostate cancer risk: a nested case-control study in the Multiethnic Cohort,” British Journal of Cancer, vol. 101, no. 1, pp. 185–191, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. M. D. Jackson, N. D. McFarlane-Anderson, G. A. Simon, F. I. Bennett, and S. P. Walker, “Urinary phytoestrogens and risk of prostate cancer in Jamaican men,” Cancer Causes and Control, vol. 21, no. 12, pp. 2249–2257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. M. M. Nguyen, F. R. Ahmann, R. B. Nagle et al., “Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities,” Cancer Prevention Research, vol. 5, no. 2, pp. 290–298, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. J.-M. Yuan, Y.-T. Gao, C. S. Yang, and M. C. Yu, “Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study,” International Journal of Cancer, vol. 120, no. 6, pp. 1344–1350, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. C. L. Sun, J. M. Yuan, M. J. Lee et al., “Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China,” Carcinogenesis, vol. 23, no. 9, pp. 1497–1503, 2002. View at Publisher · View at Google Scholar · View at Scopus
  51. K.-P. Ko, S. K. Park, B. Park et al., “Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort,” Cancer Epidemiology Biomarkers & Prevention, vol. 19, no. 5, pp. 1292–1300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Hara, S. Sasazuki, M. Inoue et al., “Plasma isoflavone concentrations are not associated with gastric cancer risk among japanese men and women,” Journal of Nutrition, vol. 143, no. 8, pp. 1293–1298, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. T. Shimazu, M. Inoue, S. Sasazuki et al., “Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 3, pp. 419–427, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Luo, L. Tang, M. Tang et al., “Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine,” Carcinogenesis, vol. 27, no. 2, pp. 262–268, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. P. C. H. Hollman, J. H. M. de Vries, S. D. van Leeuwen, M. J. B. Mengelers, and M. B. Katan, “Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers,” The American Journal of Clinical Nutrition, vol. 62, no. 6, pp. 1276–1282, 1995. View at Google Scholar · View at Scopus
  56. K. C. Ock, J. C. Sang, and W. O. Song, “Estimated dietary flavonoid intake and major food sources of U.S. adults,” Journal of Nutrition, vol. 137, no. 5, pp. 1244–1252, 2007. View at Google Scholar · View at Scopus
  57. A. J. Day, F. Mellon, D. Barron, G. Sarrazin, M. R. A. Morgan, and G. Williamson, “Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin,” Free Radical Research, vol. 35, no. 6, pp. 941–952, 2001. View at Publisher · View at Google Scholar · View at Scopus
  58. E. U. Graefe, J. Wittig, S. Mueller et al., “Pharmacokinetics and bioavailability of quercetin glycosides in humans,” The Journal of Clinical Pharmacology, vol. 41, no. 5, pp. 492–499, 2001. View at Publisher · View at Google Scholar · View at Scopus
  59. J. H. Moon, R. Nakata, S. Oshima, T. Inakuma, and J. Terao, “Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 279, no. 2, pp. R461–R467, 2000. View at Google Scholar · View at Scopus
  60. C. Manach, C. Morand, A. Gil-Izquierdo, C. Bouteloup-Demange, and C. Rémésy, “Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two dose of orange juice,” European Journal of Clinical Nutrition, vol. 57, no. 2, pp. 235–242, 2003. View at Publisher · View at Google Scholar · View at Scopus
  61. J. T. Kumpulainen, “Intake of flavonoids, phenolic acids and lignans in various populations,” in Proceedings of the 3rd International Conference on Natural Antioxidants and Anticarcinogens in Food, Health and Disease, Kuopion University Publications D. Medical Sciences, Kuopio, Finland, 2001.
  62. M. Kano, T. Takayanagi, K. Harada, S. Sawada, and F. Ishikawa, “Bioavailability of isoflavones after ingestion of soy beverages in healthy adults,” Journal of Nutrition, vol. 136, no. 9, pp. 2291–2296, 2006. View at Google Scholar · View at Scopus
  63. K. Wakai, I. Egami, K. Kato et al., “Dietary intake and sources of isoflavones among Japanese,” Nutrition and Cancer, vol. 33, no. 2, pp. 139–145, 1999. View at Publisher · View at Google Scholar · View at Scopus
  64. Z. Chen, W. Zheng, L. J. Custer et al., “Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai,” Nutrition and Cancer, vol. 33, no. 1, pp. 82–87, 1999. View at Publisher · View at Google Scholar · View at Scopus
  65. T. Izumi, M. K. Piskula, S. Osawa et al., “Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans,” Journal of Nutrition, vol. 130, no. 7, pp. 1695–1699, 2000. View at Google Scholar · View at Scopus
  66. K. D. R. Setchell, N. M. Brown, P. Desai et al., “Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements,” Journal of Nutrition, vol. 131, no. 4, supplement, pp. 1362S–1375S, 2001. View at Google Scholar · View at Scopus
  67. K. D. R. Setchell, M. S. Faughnan, T. Avades et al., “Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women,” The American Journal of Clinical Nutrition, vol. 77, no. 2, pp. 411–419, 2003. View at Google Scholar · View at Scopus
  68. D. L. McKay and J. B. Blumberg, “The role of tea in human health: an update,” Journal of the American College of Nutrition, vol. 21, no. 1, pp. 1–13, 2002. View at Publisher · View at Google Scholar · View at Scopus
  69. D. A. Balentine, S. A. Wiseman, and L. C. M. Bouwens, “The chemistry of tea flavonoids,” Critical Reviews in Food Science and Nutrition, vol. 37, no. 8, pp. 693–704, 1997. View at Publisher · View at Google Scholar · View at Scopus
  70. O. J. Park and Y.-J. Surh, “Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies,” Toxicology Letters, vol. 150, no. 1, pp. 43–56, 2004. View at Publisher · View at Google Scholar · View at Scopus
  71. M. J. Lee, Z. Y. Wang, H. Li et al., “Analysis of plasma and urinary tea polyphenols in human subjects,” Cancer Epidemiology Biomarkers and Prevention, vol. 4, no. 4, pp. 393–399, 1995. View at Google Scholar · View at Scopus
  72. J. M. M. Van Amelsvoort, K. H. Van Het Hof, J. N. J. J. Mathot, T. P. J. Mulder, A. Wiersma, and L. B. M. Tijburg, “Plasma concentrations of individual tea catechins after a single oral dose in humans,” Xenobiotica, vol. 31, no. 12, pp. 891–901, 2001. View at Publisher · View at Google Scholar · View at Scopus
  73. M.-J. Lee, P. Maliakal, L. Chen et al., “Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 10, pp. 1025–1032, 2002. View at Google Scholar · View at Scopus
  74. H.-H. S. Chow, Y. Cai, D. S. Alberts et al., “Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E,” Cancer Epidemiology Biomarkers & Prevention, vol. 10, no. 1, pp. 53–58, 2001. View at Google Scholar · View at Scopus
  75. J. Pérez-Jiménez, J. Hubert, L. Hooper et al., “Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review,” The American Journal of Clinical Nutrition, vol. 92, no. 4, pp. 801–809, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. T. J. Key, “Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies,” Journal of the National Cancer Institute, vol. 94, no. 8, pp. 606–616, 2002. View at Publisher · View at Google Scholar · View at Scopus
  77. J. Ferlay, I. Soerjomataram, M. Ervik et al., GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11, International Agency for Research on Cancer, Lyon, France, 2012, http://globocan.iarc.fr.
  78. T. Huang, J. Yu, L. Tang et al., “Phase IIa chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: I. Design, clinical outcome, and baseline biomarker data,” International Journal of Cancer Prevention, vol. 1, no. 4, pp. 269–280, 2004. View at Google Scholar
  79. J.-S. Wang, T. Huang, and J. Yu, “Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer,” Proceedings of American Association of Cancer Research, vol. 44, 2003. View at Google Scholar
  80. H. Luo, S. B. Cox, W.-M. Gao, J. Yu, L. Tang, and J.-S. Wang, “Metabolic profiling in validation of plasma biomarkers for green tea polyphenols,” Metabolomics, vol. 2, no. 4, pp. 235–241, 2006. View at Publisher · View at Google Scholar · View at Scopus
  81. H. Luo, L. Tang, M. Tang et al., “Validation of green tea polyphenol biomarkers in high-risk population of liver cancer,” in Proceedings of the 95th Annual Meeting of American Association of Cancer Research, vol. 45, p. 931, Orlando, Fla, USA, March 2004.
  82. A. Pilger, D. Germadnik, K. Riedel, I. Meger-Kossien, G. Scherer, and H. Rüdiger, “Longitudinal study of urinary 8-hydroxy-2′-deoxyguanosine excretion in healthy adults,” Free Radical Research, vol. 35, no. 3, pp. 273–280, 2001. View at Publisher · View at Google Scholar · View at Scopus
  83. L. Tang, M. Tang, L. Xu et al., “Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention,” Carcinogenesis, vol. 29, no. 2, pp. 411–417, 2008. View at Publisher · View at Google Scholar · View at Scopus
  84. J. Yu, T. Huang, L. Zhang et al., “Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer in southern Guangxi, China,” in Proceedings of the American Association of Cancer Research, vol. 2006, p. 1148, 2006.
  85. Y. L. Low, J. I. Taylor, P. B. Grace et al., “Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men,” Journal of Nutrition, vol. 135, no. 11, pp. 2680–2686, 2005. View at Google Scholar · View at Scopus
  86. M. Inoue, K. Robien, R. Wang, D. J. Van Den Berg, W.-P. Koh, and M. C. Yu, “Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study,” Carcinogenesis, vol. 29, no. 10, pp. 1967–1972, 2008. View at Publisher · View at Google Scholar · View at Scopus
  87. M. Iwasaki, G. S. Hamada, I. N. Nishimoto et al., “Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians,” Cancer Science, vol. 100, no. 5, pp. 927–933, 2009. View at Publisher · View at Google Scholar · View at Scopus
  88. T. K. Lam, M. Rotunno, J. H. Lubin et al., “Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk,” Carcinogenesis, vol. 31, no. 4, pp. 634–642, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. I.-H. Lin, M.-L. Ho, H.-Y. Chen et al., “Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk,” PLoS ONE, vol. 7, no. 2, Article ID e30951, 2012. View at Publisher · View at Google Scholar · View at Scopus
  90. J. J. Yang, L. Y. Cho, K.-P. Ko et al., “Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort,” Molecular Nutrition and Food Research, vol. 56, no. 11, pp. 1617–1626, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. J.-M. Yuan, W.-P. Koh, C.-L. Sun, H.-P. Lee, and M. C. Yu, “Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore,” Carcinogenesis, vol. 26, no. 8, pp. 1389–1394, 2005. View at Publisher · View at Google Scholar · View at Scopus
  92. A. Link, F. Balaguer, and A. Goel, “Cancer chemoprevention by dietary polyphenols: promising role for epigenetics,” Biochemical Pharmacology, vol. 80, no. 12, pp. 1771–1792, 2010. View at Publisher · View at Google Scholar · View at Scopus
  93. M. Fang, D. Chen, and C. S. Yang, “Dietary polyphenols may affect DNA methylation,” Journal of Nutrition, vol. 137, no. 1, supplement, pp. 223S–228S, 2007. View at Google Scholar · View at Scopus
  94. D. del Rio, L. G. Costa, M. E. J. Lean, and A. Crozier, “Polyphenols and health: what compounds are involved?” Nutrition, Metabolism and Cardiovascular Diseases, vol. 20, no. 1, pp. 1–6, 2010. View at Publisher · View at Google Scholar · View at Scopus