Oxidative Medicine and Cellular Longevity / 2015 / Article / Tab 1

Review Article

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Table 1

Summary of Nrf2 expression, Nrf2 target expression, and Nrf2 activity in long-lived models.

ModelTissue/cell typeNrf2 expressionNrf2 target expression
(NQOl, HO-1, SOD-1, etc.)
Nrf2 activity
(Nrf2-ARE binding)

Naked mole ratLiver[25]

Caloric restrictionHeartN.R.This manuscript

RapamycinSkMN.R.This manuscript
C. elegans [28]

SnellSkMN.R.This manuscript
HeartN.R.This manuscript

Crowded litterSkMN.R.This manuscript


Arrows indicate difference in the long-lived model compared to corresponding control, with ↑ indicating “greater in the long-lived model compared to control,” indicating “no difference between long-lived model and control,” and N.R. indicating “data were not reported in the investigation.” To date, no experimental data for Nrf2 expression or activity have been reported in aged humans. CMVEC: cerebromicrovascular endothelial cells; SkM: skeletal muscle (mixed skeletal muscle: gastrocnemius, soleus, and plantaris).