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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 3571614, 10 pages
Review Article

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China

Received 29 October 2014; Revised 2 January 2015; Accepted 12 January 2015

Academic Editor: Matías Mosqueira

Copyright © 2016 Chunye Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) is an orally bioavailable phytochemical, extensively found in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops and is known to exhibit antioxidant, anti-inflammatory, anticancer, antimutagenic, antiglycemic, neuroprotective, and antibacterial activities. The literature reveals that sinapic acid is a bioactive phenolic acid and has the potential to attenuate various chemically induced toxicities. This minireview is an effort to summarize the available literature about pharmacokinetic, therapeutic, and protective potential of this versatile molecule in health related areas.