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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 4528906, 11 pages
http://dx.doi.org/10.1155/2016/4528906
Research Article

Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis

1Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2Department of Inpatient Abdominal Ultrasonography, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
3Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Received 16 June 2015; Revised 19 August 2015; Accepted 23 August 2015

Academic Editor: Rakesh K. Singh

Copyright © 2016 Yuehong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Cardiomyocytes were treated with Pin1 inhibitor Juglone (2.5 μM). Cells treated with Juglone demonstrated lower cell viability and higher apoptosis in both condition without or with alcohol treatment. Since Pin1 has been reported to be a strong cytotoxic agent and induce apoptosis in many cell type, the apoptosis-inducing activity of Juglone in cardiomyocytes might be through other signaling pathways than inhibiting Pin1.

  1. Supplementary Material