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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 4984597, 10 pages
http://dx.doi.org/10.1155/2016/4984597
Research Article

Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice

1Department of Physiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
2Department of Materials Sciences, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305–8573, Japan
3Master’s School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba 305–8573, Japan
4Satellite Laboratory, International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), University of Tsukuba, Tennodai 1-1-1, Tsukuba 305–8573, Japan

Received 28 November 2015; Revised 30 January 2016; Accepted 11 February 2016

Academic Editor: Victor M. Victor

Copyright © 2016 Phetcharat Boonruamkaew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to evaluate the hepatoprotective effect of an antioxidative nanoparticle () recently developed against APAP-induced hepatotoxicity in mice. The effects of oral administration of to APAP-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (ALT) activity, aspartate transaminase (AST) activity, alkaline phosphatase (ALP) activity, prothrombin time, and serum albumin (ALB) level. The treatment effects were assessed in terms of free radical parameters: malondialdehyde (MDA) accumulation, glutathione peroxidase (GPx) activity, % inhibition of superoxide anion (), and histopathological examination. The N-acetylcysteine (NAC)-treated group exhibited an enhanced prothrombin time relative to the control group, while did not prolong prothrombin time. The -treated animals exhibited lower levels of ALT, AST, and ALP, while increased ALB levels were measured in these animals compared to those in the other groups. The -treated animals furthermore exhibited improved MDA levels, GPx activity, and % inhibition of , which relate to oxidative damage. Histological staining of liver tissues from -treated animals did not reveal any microscopic changes relative to the other groups. The findings of this study suggest that possesses effective hepatoprotective properties and does not exhibit the notable adverse effects associated with NAC treatment.