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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 5213532, 10 pages
http://dx.doi.org/10.1155/2016/5213532
Research Article

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

1Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
2Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
3Department of Pharmacognosy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
4Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague, Kateřinská 1660/32, 121 08 Prague, Czech Republic
5Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Charles University in Prague, Sokolská 581, 500 05 Hradec Králové, Czech Republic
64th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 128 02 Prague, Czech Republic

Received 13 August 2015; Accepted 15 September 2015

Academic Editor: Luciano Saso

Copyright © 2016 Michal Říha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Cell morphology and nuclear epifluorescence co-staining with Hoechst 33342 and propidium iodide of H9c2 cardiomyoblasts.

Figure S2: The effect of D-PA on haemodynamic parameters: mean blood pressure (a), heart rate (b), stroke volume (c) and ejection fraction (d). Statistical significance vs control: * p < 0.05, ** p < 0.01 vs control.

  1. Supplementary Material