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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 5271251, 11 pages
Research Article

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

1Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
2Department of Drug Science and Technology, University of Turin, Torino, Italy
3Department of Life Sciences and Systems Biology, University of Turin, Torino, Italy

Received 7 September 2016; Revised 12 October 2016; Accepted 23 October 2016

Academic Editor: Cecilia Zazueta

Copyright © 2016 Raffaella Mastrocola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Online Supplementary Data show a summary of the main drug data, including chemical structure, Molecular Weight, and method of synthesis. Besides, a brief report of previously published in vitro data, showing the specificity of the NLRP3 inflammasome inhibitor, are here reported. Specifically, we show results demonstrating the inhibitory effect of INF4E on pyroptotic cell death and NLRP3 ATPase and Caspase-1 activities. We also show that INF4E does not affect the activation of the Keap1-Nrf2 pathway, which is known to play a major role in cellular defense against oxidants and electrophiles.

  1. Supplementary Material