Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 5380319, 10 pages
http://dx.doi.org/10.1155/2016/5380319
Research Article

Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

1Department of Health, Jinan Central Hospital, Shandong University, Jinan, China
2Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, China
3Central Laboratory, Jinan Central Hospital, Shandong University, Jinan, China
4Department of Cardiology, Qianfoshan Hospital, Shandong University, Jinan, China

Received 23 February 2016; Revised 25 March 2016; Accepted 3 April 2016

Academic Editor: Mohanraj Rajesh

Copyright © 2016 Fang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Umberger, B. Callen, and M. L. Brown, “Severe sepsis in older adults,” Critical Care Nursing Quarterly, vol. 38, no. 3, pp. 259–270, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Carbajal-Guerrero, A. Cayuela-Domínguez, E. Fernández-García et al., “Epidemiology and long-term outcome of sepsis in elderly patients,” Medicina Intensiva, vol. 38, no. 1, pp. 21–32, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Nasa, D. Juneja, and O. Singh, “Severe sepsis and septic shock in the elderly: an overview,” World Journal of Critical Care Medicine, vol. 1, no. 1, pp. 23–30, 2012. View at Publisher · View at Google Scholar
  4. H. Palomba, T. D. Corrêa, E. Silva, A. Pardini, and M. S. de Assuncao, “Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients,” Einstein, vol. 13, no. 3, pp. 357–363, 2015. View at Publisher · View at Google Scholar
  5. D. Heymann, “Autophagy: a protective mechanism in response to stress and inflammation,” Current Opinion in Investigational Drugs, vol. 7, no. 5, pp. 443–450, 2006. View at Google Scholar · View at Scopus
  6. D. C. Rubinsztein, G. Mariño, and G. Kroemer, “Autophagy and aging,” Cell, vol. 146, no. 5, pp. 682–695, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Knuppertz and H. D. Osiewacz, “Orchestrating the network of molecular pathways affecting aging: role of nonselective autophagy and mitophagy,” Mechanisms of Ageing and Development, vol. 153, pp. 30–40, 2016. View at Publisher · View at Google Scholar
  8. L. J. Leon and Å. B. Gustafsson, “Staying young at heart: autophagy and adaptation to cardiac aging,” Journal of Molecular and Cellular Cardiology, 2015. View at Publisher · View at Google Scholar
  9. C. Settembre and A. Ballabio, “TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes,” Autophagy, vol. 7, no. 11, pp. 1379–1381, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Palmieri, S. Impey, H. Kang et al., “Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways,” Human Molecular Genetics, vol. 20, no. 19, Article ID ddr306, pp. 3852–3866, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Wu, S. Xia, B. Kalionis, W. Wan, and T. Sun, “The role of oxidative stress and inflammation in cardiovascular aging,” BioMed Research International, vol. 2014, Article ID 615312, 13 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. D.-F. Dai and P. S. Rabinovitch, “Cardiac aging in mice and humans: the role of mitochondrial oxidative stress,” Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 213–220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Pacher, J. S. Beckman, and L. Liaudet, “Nitric oxide and peroxynitrite in health and disease,” Physiological Reviews, vol. 87, no. 1, pp. 315–424, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Hao, F. Lang, Y. Chen et al., “Resveratrol alleviates endotoxin-induced myocardial toxicity via the Nrf2 transcription factor,” PLoS ONE, vol. 8, no. 7, Article ID e69452, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Hao, P. Mukhopadhyay, Z. Cao et al., “Cannabidiol protects against doxorubicin-induced cardiomyopathy by modulating mitochondrial function and biogenesis,” Molecular Medicine, vol. 21, pp. 38–45, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Lang, Z. Qin, F. Li, H. Zhang, Z. Fang, and E. Hao, “Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells,” PLoS ONE, vol. 10, no. 6, Article ID e0129196, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. M. K. ElZarrad, P. Mukhopadhyay, N. Mohan et al., “Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice,” PLoS ONE, vol. 8, no. 11, Article ID e79543, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Bátkai, M. Rajesh, P. Mukhopadhyay et al., “Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 293, no. 2, pp. H909–H918, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Boengler, A. Buechert, Y. Heinen et al., “Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice,” Circulation Research, vol. 102, no. 1, pp. 131–135, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. R. M. Grocott-Mason and A. M. Shah, “Cardiac dysfunction in sepsis: new theories and clinical implications,” Intensive Care Medicine, vol. 24, no. 4, pp. 286–295, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. A. F. Suffredini, R. E. Fromm, M. M. Parker et al., “The cardiovascular response of normal humans to the administration of endotoxin,” The New England Journal of Medicine, vol. 321, no. 5, pp. 280–287, 1989. View at Publisher · View at Google Scholar · View at Scopus
  23. S.-Y. Li, M. Du, E. K. Dolence et al., “Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification,” Aging Cell, vol. 4, no. 2, pp. 57–64, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. J. M. Capasso, T. Palackal, G. Olivetti, and P. Anversa, “Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 259, no. 4, pp. H1086–H1096, 1990. View at Google Scholar · View at Scopus
  25. J. L. Fleg, “Normative aging changes in cardiovascular structure and function,” The American Journal of Geriatric Cardiology, vol. 5, pp. 7–15, 1996. View at Google Scholar
  26. E. G. Lakatta, “Changes in cardiovascular function with aging,” European Heart Journal, vol. 11, pp. 22–29, 1990. View at Publisher · View at Google Scholar · View at Scopus
  27. M. D. Cheitlin, “Cardiovascular physiology—changes with aging,” The American Journal of Geriatric Cardiology, vol. 12, no. 1, pp. 9–13, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. R. S. Whelan, V. Kaplinskiy, and R. N. Kitsis, “Cell death in the pathogenesis of heart disease: mechanisms and significance,” Annual Review of Physiology, vol. 72, pp. 19–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. S. L. Fink and B. T. Cookson, “Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells,” Infection and Immunity, vol. 73, no. 4, pp. 1907–1916, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. R. S. Vasan, L. M. Sullivan, R. Roubenoff et al., “Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study,” Circulation, vol. 107, no. 11, pp. 1486–1491, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Baynes and D. B. Murray, “Cardiac and renal function are progressively impaired with aging in Zucker diabetic fatty type II diabetic rats,” Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 328–334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Coggins and A. Rosenzweig, “The fire within: cardiac inflammatory signaling in health and disease,” Circulation Research, vol. 110, no. 1, pp. 116–125, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. J. W. Gordon, J. A. Shaw, and L. A. Kirshenbaum, “Multiple facets of NF-κB in the heart: to be or not to NF-κB,” Circulation Research, vol. 108, no. 9, pp. 1122–1132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. Q. S. Zang, S. E. Wolf, and J. P. Minei, “Sepsis-induced cardiac mitochondrial damage and potential therapeutic interventions in the elderly,” Aging and Disease, vol. 5, no. 2, pp. 137–149, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Radi, “Nitric oxide, oxidants, and protein tyrosine nitration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 12, pp. 4003–4008, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. M. M. Elahi, Y. X. Kong, and B. M. Matata, “Oxidative stress as a mediator of cardiovascular disease,” Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 259–269, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Mukhopadhyay, M. Rajesh, S. Bátkai et al., “Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 296, no. 5, pp. H1466–H1483, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Nishida, M. Taneike, and K. Otsu, “The role of autophagic degradation in the heart,” Journal of Molecular and Cellular Cardiology, vol. 78, pp. 73–79, 2015. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Settembre, C. Di Malta, V. A. Polito et al., “TFEB links autophagy to lysosomal biogenesis,” Science, vol. 332, no. 6036, pp. 1429–1433, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. E. E. Essick and F. Sam, “Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer,” Oxidative Medicine and Cellular Longevity, vol. 3, no. 3, pp. 168–177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. Å. B. Gustafsson and R. A. Gottlieb, “Recycle or die: the role of autophagy in cardioprotection,” Journal of Molecular and Cellular Cardiology, vol. 44, no. 4, pp. 654–661, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. C. Huang, S. Yitzhaki, C. N. Perry et al., “Autophagy induced by ischemic preconditioning is essential for cardioprotection,” Journal of Cardiovascular Translational Research, vol. 3, no. 4, pp. 365–373, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Nakai, O. Yamaguchi, T. Takeda et al., “The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress,” Nature Medicine, vol. 13, no. 5, pp. 619–624, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. E. J. Feeney, C. Spampanato, R. Puertollano, A. Ballabio, G. Parenti, and N. Raben, “What else is in store for autophagy? Exocytosis of autolysosomes as a mechanism of TFEB-mediated cellular clearance in Pompe disease,” Autophagy, vol. 9, no. 7, pp. 1117–1118, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Decressac, B. Mattsson, P. Weikop, M. Lundblad, J. Jakobsson, and A. Björklund, “TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 19, pp. E1817–E1826, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Terman and U. T. Brunk, “Autophagy in cardiac myocyte homeostasis, aging, and pathology,” Cardiovascular Research, vol. 68, no. 3, pp. 355–365, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Kostin, L. Pool, A. Elsässer et al., “Myocytes die by multiple mechanisms in failing human hearts,” Circulation Research, vol. 92, no. 7, pp. 715–724, 2003. View at Publisher · View at Google Scholar · View at Scopus