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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6705621, 12 pages
http://dx.doi.org/10.1155/2016/6705621
Research Article

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

1Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
2College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China

Received 15 April 2015; Revised 2 August 2015; Accepted 31 August 2015

Academic Editor: David Sebastián

Copyright © 2016 Kaige Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has been confirmed that mitochondrial impairment may underlie both sporadic and familial Parkinson’s disease (PD). Mitochondrial fission/fusion and biogenesis are key processes in regulating mitochondrial homeostasis. Therefore, we explored whether the protective effect of resveratrol in rotenone-induced neurotoxicity was associated with mitochondrial fission/fusion and biogenesis. The results showed that resveratrol could not only promote mitochondrial mass and DNA copy number but also improve mitochondrial homeostasis and neuron function in rats and PC12 cells damaged by rotenone. We also observed effects with alterations in proteins known to regulate mitochondrial fission/fusion and biogenesis in rotenone-induced neurotoxicity. Therefore, our findings suggest that resveratrol may prevent rotenone-induced neurotoxicity through regulating mitochondrial fission/fusion and biogenesis.