Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6705621, 12 pages
http://dx.doi.org/10.1155/2016/6705621
Research Article

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

1Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
2College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China

Received 15 April 2015; Revised 2 August 2015; Accepted 31 August 2015

Academic Editor: David Sebastián

Copyright © 2016 Kaige Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Blanchet, F. Longpré, G. Bureau et al., “Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice,” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 32, no. 5, pp. 1243–1250, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Pangeni, J. K. Sahni, J. Ali, S. Sharma, and S. Baboota, “Resveratrol: review on therapeutic potential and recent advances in drug delivery,” Expert Opinion on Drug Delivery, vol. 11, no. 8, pp. 1285–1298, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. V. W. Dolinsky, A. Y. M. Chan, I. R. Frayne, P. E. Light, C. Des Rosiers, and J. R. B. Dyck, “Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1,” Circulation, vol. 119, no. 12, pp. 1643–1652, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. K.-F. Hsu, C.-L. Wu, S.-C. Huang et al., “Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells,” Autophagy, vol. 5, no. 4, pp. 451–460, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Lagouge, C. Argmann, Z. Gerhart-Hines et al., “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha,” Cell, vol. 127, no. 6, pp. 1109–1122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. D. D. Lofrumento, G. Nicolardi, A. Cianciulli et al., “Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson's-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses,” Innate Immunity, vol. 20, no. 3, pp. 249–260, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Jin, Q. Wu, Y.-F. Lu, Q.-H. Gong, and J.-S. Shi, “Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats,” European Journal of Pharmacology, vol. 600, no. 1–3, pp. 78–82, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J.-H. Shin, V. L. Dawson, and T. M. Dawson, “SnapShot: pathogenesis of Parkinson's disease,” Cell, vol. 139, no. 2, pp. 440.e1–440.e2, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Perier, J. Bové, M. Vila, and S. Przedborski, “The rotenone model of Parkinson's disease,” Trends in neurosciences, vol. 26, no. 7, pp. 345–346, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. C. M. Tanner, F. Kame, G. W. Ross et al., “Rotenone, paraquat, and Parkinson's disease,” Environmental Health Perspectives, vol. 119, no. 6, pp. 866–872, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Spivey, “Rotenone and paraquat linked to Parkinson's disease: human exposure study supports years of animal studies,” Environmental Health Perspectives, vol. 119, no. 6, article A259, 2011. View at Google Scholar · View at Scopus
  12. A. Abeliovich, “Parkinson's disease: mitochondrial damage control,” Nature, vol. 463, no. 7282, pp. 744–745, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Friedman and J. Nunnari, “Mitochondrial form and function,” Nature, vol. 505, no. 7483, pp. 335–343, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Nunnari and A. Suomalainen, “Mitochondria: in sickness and in health,” Cell, vol. 148, no. 6, pp. 1145–1159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. D. C. Chan, “Mitochondria: dynamic organelles in disease, aging, and development,” Cell, vol. 125, no. 7, pp. 1241–1252, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Cui, H. Jeong, F. Borovecki, C. N. Parkhurst, N. Tanese, and D. Krainc, “Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration,” Cell, vol. 127, no. 1, pp. 59–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Milone, “Mitochondria, diabetes, and Alzheimer's disease,” Diabetes, vol. 61, no. 5, pp. 991–992, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Wang, Y. Y. Liu, X. Y. Liu et al., “Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model,” Cellular Physiology and Biochemistry, vol. 34, no. 3, pp. 854–864, 2014. View at Publisher · View at Google Scholar
  19. J. S. Franzone and M. C. Reboani, “Stimulating action of hematoporphyrin on motor coordination and resistance to fatigue in rats,” Archivio per le Scienze Mediche, vol. 134, no. 4, pp. 403–406, 1977. View at Google Scholar · View at Scopus
  20. J. F. Buckman, H. Hernandez, G. J. Kress, T. V. Votyakova, S. Pal, and I. J. Reynolds, “MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants,” Journal of Neuroscience Methods, vol. 104, no. 2, pp. 165–176, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Agnello, G. Morici, and A. M. Rinaldi, “A method for measuring mitochondrial mass and activity,” Cytotechnology, vol. 56, no. 3, pp. 145–149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. L. F. Marques-Santos, J. G. P. Oliveira, R. C. Maia, and V. M. Rumjanek, “Mitotracker green is a P-glycoprotein substrate,” Bioscience Reports, vol. 23, no. 4, pp. 199–212, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Hoppins and J. Nunnari, “Mitochondrial dynamics and apoptosis—the ER connection,” Science, vol. 337, no. 6098, pp. 1052–1054, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. O. Dietrich, Z.-W. Liu, and T. L. Horvath, “Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity,” Cell, vol. 155, no. 1, pp. 188–199, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Tamura, K. Itoh, and H. Sesaki, “SnapShot: mitochondrial dynamics,” Cell, vol. 145, no. 7, pp. 1158–1158.e1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. Z. Wu, P. Puigserver, U. Andersson et al., “Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1,” Cell, vol. 98, no. 1, pp. 115–124, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Z. Agudelo, T. Femenia, F. Orhan et al., “Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression,” Cell, vol. 159, no. 1, pp. 33–45, 2014. View at Publisher · View at Google Scholar
  28. R. J. Youle and A. M. van der Bliek, “Mitochondrial fission, fusion, and stress,” Science, vol. 337, no. 6098, pp. 1062–1065, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Jiang, H. Bo, C. Song et al., “Increased vulnerability with aging to MPTP: the mechanisms underlying mitochondrial dynamics,” Neurological Research, vol. 36, no. 8, pp. 722–732, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Filomeni, I. Graziani, D. De Zio et al., “Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease,” Neurobiology of Aging, vol. 33, no. 4, pp. 767–785, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. T.-K. Lin, S.-D. Chen, Y.-C. Chuang et al., “Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy,” International Journal of Molecular Sciences, vol. 15, no. 1, pp. 1625–1646, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. D. M. Arduíno, A. R. Esteves, and S. M. Cardoso, “Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: when mitochondria get nasty,” Parkinson's Disease, vol. 2011, Article ID 767230, 13 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Westermann, “Mitochondrial fusion and fission in cell life and death,” Nature Reviews Molecular Cell Biology, vol. 11, no. 12, pp. 872–884, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Westermann, “Bioenergetic role of mitochondrial fusion and fission,” Biochimica et Biophysica Acta: Bioenergetics, vol. 1817, no. 10, pp. 1833–1838, 2012. View at Publisher · View at Google Scholar · View at Scopus