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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7174351, 8 pages
http://dx.doi.org/10.1155/2016/7174351
Research Article

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

1Pharmacology Department, National Research Center, El Buhouth Street, Dokki, Giza 12311, Egypt
2Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3Zoology Department, College of Science, Minia University, Minia 11432, Egypt

Received 22 October 2015; Revised 7 December 2015; Accepted 15 December 2015

Academic Editor: Ilaria Peluso

Copyright © 2016 Samir A. E. Bashandy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Wang, L. Qi, M. R. Moore, and J. C. Ng, “A review of animal models for the study of arsenic carcinogenesis,” Toxicology Letters, vol. 133, no. 1, pp. 17–31, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Lengfelder, W.-K. Hofmann, and D. Nowak, “Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia,” Leukemia, vol. 26, no. 3, pp. 433–442, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Sarkar, G. R. Chaudhuri, A. Chattopadhyay, and N. M. Biswas, “Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats,” Asian Journal of Andrology, vol. 5, no. 1, pp. 27–31, 2003. View at Google Scholar · View at Scopus
  4. N. Pant, R. C. Murthy, and S. P. Srivastava, “Male reproductive toxicity of sodium arsenite in mice,” Human and Experimental Toxicology, vol. 23, no. 8, pp. 399–403, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. S. I. Chang, B. Jin, P. Youn, C. Park, J.-D. Park, and D.-Y. Ryu, “Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis,” Toxicology and Applied Pharmacology, vol. 218, no. 2, pp. 196–203, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Das, J. Ghosh, P. Manna, M. Sinha, and P. C. Sil, “Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways,” Toxicology Letters, vol. 187, no. 3, pp. 201–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Ramanathan, M. Anusuyadevi, S. Shila, and C. Panneerselvam, “Ascorbic acid and α-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats,” Toxicology Letters, vol. 156, no. 2, pp. 297–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. M. Hoseini, K. Khosravi-Darani, and M. R. Mozafari, “Nutritional and medical applications of spirulina microalgae,” Mini-Reviews in Medicinal Chemistry, vol. 13, no. 8, pp. 1231–1237, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Ferreira-Hermosillo, P. V. Torres-Duran, and M. A. Juarez-Oropeza, “Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series,” Journal of Medical Case Reports, vol. 4, no. 103, pp. 1–5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Deng and T.-J. Chow, “Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae spirulina,” Cardiovascular Therapeutics, vol. 28, no. 4, pp. e33–e45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. K. Coskun, M. Kerem, N. Gurbuz et al., “The study of biochemical and histopathological effects of spirulina in rats with TNBS-induced colitis,” Bratislava Medical Journal, vol. 112, no. 5, pp. 235–243, 2011. View at Google Scholar · View at Scopus
  12. M. F. Ismail, D. A. Ali, A. Fernando et al., “Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina,” International Journal of Biological Sciences, vol. 5, no. 4, pp. 377–387, 2009. View at Google Scholar · View at Scopus
  13. M. Khan, J. C. Shobha, I. K. Mohan et al., “Protective effect of Spirulina against doxorubicin-induced cardiotoxicity,” Phytotherapy Research, vol. 19, no. 12, pp. 1030–1037, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. P. D. Karkos, S. C. Leong, C. D. Karkos, N. Sivaji, and D. A. Assimakopoulos, “Spirulina in clinical practice: evidence-based human applications,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 531053, 4 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Romay, J. Armesto, D. Remirez, R. González, N. Ledon, and I. García, “Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae,” Inflammation Research, vol. 47, no. 1, pp. 36–41, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. V. B. Bhat and K. M. Madyastha, “Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA,” Biochemical and Biophysical Research Communications, vol. 285, no. 2, pp. 262–266, 2001. View at Google Scholar
  17. E. A. Lissi, M. Pizarro, A. Aspee, and C. Romay, “Kinetics of phycocyanine bilin groups destruction by peroxyl radicals,” Free Radical Biology and Medicine, vol. 28, no. 7, pp. 1051–1055, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. S. V. S. Rana, “Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat,” Indian Journal of Experimental Biology, vol. 45, no. 4, pp. 371–375, 2007. View at Google Scholar · View at Scopus
  19. E. S. Gelagutashvili, A. I. Belokobyl'skii, A. N. Rcheulishvili, and L. M. Mosulishvili, “Interaction of Pb(II) ions with C-phycocyanin from Spirulina platensis: effect of ionic strength,” Biofizika, vol. 48, no. 4, pp. 589–594, 2003. View at Google Scholar
  20. G. E. El-Desoky, S. A. Bashandy, I. M. Alhazza, Z. A. Al-Othman, M. A. M. Aboul-Soud, and K. Yusuf, “Improvement of mercuric chloride-induced testis injuries and sperm quality deteriorations by Spirulina platensis in rats,” PLoS ONE, vol. 8, no. 3, Article ID e59177, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Lewis and J. Saxs, Dangerous Properties of Industrial Materials, V. N. Reinhold, New York, NY, USA, 9th edition, 1996.
  22. N. Simsek, A. Karadeniz, Y. Kalkan, O. N. Keles, and B. Unal, “Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats,” Journal of Hazardous Materials, vol. 164, no. 2-3, pp. 1304–1309, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Sengupta, “A scientific review of age determination for a laboratory rat: how old is it in comparison with human age?” Biomedicine International, vol. 2, pp. 81–89, 2011. View at Google Scholar
  24. K. Narayana, N. Prashanthi, A. Nayanatara, H. H. C. Kumar, K. Abhilash, and K. L. Bairy, “Effects of methyl parathion (o,o-dimethyl o-4-nitrophenyl phosphorothioate) on rat sperm morphology and sperm count, but not fertility, are associated with decreased ascorbic acid level in the testis,” Mutation Research, vol. 588, no. 1, pp. 28–34, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. Y.-C. Chen, S.-Y. N. Lin-Shiau, and J.-K. Lin, “Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis,” Journal of Cellular Physiology, vol. 177, no. 2, pp. 324–333, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. T. I. Rasyidah, S. Suhana, H. Nur-Hidayah, M. A. Kaswandi, and R. M. Noah, “Evaluation of antioxidant activity of Zingiber officinale (ginger) on formalin—induced testicular toxicity in rats,” Journal of Medical and Bioengineering, vol. 3, no. 3, pp. 149–153, 2014. View at Publisher · View at Google Scholar
  27. J. A. Imlay and S. Linn, “DNA damage and oxygen radical toxicity,” Science, vol. 240, no. 4857, pp. 1302–1309, 1988. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Maiti and A. K. Chatterjee, “Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure and its relation to dietary protein deficiency,” Environmental Toxicology and Pharmacology, vol. 8, no. 4, pp. 227–235, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Kono and I. Fridovich, “Superoxide radical inhibits catalase,” Journal of Biological Chemistry, vol. 257, no. 10, pp. 5751–5754, 1982. View at Google Scholar · View at Scopus
  30. R. A. Zakharyan and H. V. Aposhian, “Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase,” Chemical Research in Toxicology, vol. 12, no. 12, pp. 1278–1283, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. T. R. Radabaugh and H. V. Aposhian, “Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase,” Chemical Research in Toxicology, vol. 13, no. 1, pp. 26–30, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. V. K. Mazo, I. V. Gmoshinskii, and I. S. Zilova, “Microalgae Spirulina in human nutrition,” Voprosy Pitaniia, vol. 73, no. 1, pp. 45–53, 2004. View at Google Scholar
  33. G. Tang and P. M. Suter, “Vitamin A, nutrition, and health values of Algae: spirulina, chlorella, and dunaliella,” Journal of Pharmacy and Nutrition Sciences, vol. 1, no. 2, pp. 111–118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. L. A. Stivala, M. Savio, O. Cazzalini et al., “Effect of beta-carotene on cell cycle progression of human fibroblasts,” Carcinogenesis, vol. 17, no. 11, pp. 2395–2401, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Mueller and V. Boehm, “Antioxidant activity of β-carotene compounds in different in vitro assays,” Molecules, vol. 16, no. 2, pp. 1055–1069, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. M. C. Garg, D. P. Chaudhary, and D. D. Bansal, “Effect of vitamin E supplementation on diabetes induced oxidative stress in experimental diabetes in rats,” Indian Journal of Experimental Biology, vol. 43, no. 2, pp. 177–180, 2005. View at Google Scholar · View at Scopus
  37. F. M. El-Demerdash, “Effects of selenium and mercury on the enzymatic activities and lipid peroxidation in brain, liver, and blood of rats,” Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes, vol. 36, no. 4, pp. 489–499, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. W. Plazinski, “Binding of heavy metals by algal biosorbents, theoretical models of kinetics, equilibria and thermodynamics,” Advances in Colloid and Interface Science, vol. 197-198, pp. 58–67, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. M. H. Ali, S. A. Schlidt, N. S. Chandel, K. L. Hynes, P. T. Schumacker, and B. L. Gewertz, “Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 277, no. 5, pp. L1057–L1065, 1999. View at Google Scholar · View at Scopus
  40. N. Suematsu, H. Tsutsui, J. Wen et al., “Oxidative stress mediates tumor necrosis factor-α-induced mitochondrial DNA damage and dysfunction in cardiac myocytes,” Circulation, vol. 107, no. 10, pp. 1418–1423, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. R. M. Clancy and S. B. Abramson, “Nitric oxide: a novel mediator of inflammation,” Proceedings of the Society for Experimental Biology and Medicine, vol. 210, no. 2, pp. 93–101, 1995. View at Publisher · View at Google Scholar · View at Scopus
  42. K. Del Punta, E. H. Charreau, and O. P. Pignataro, “Nitric oxide inhibits leydig cell steroidogenesis,” Endocrinology, vol. 137, no. 12, pp. 5337–5343, 1996. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Y. Hong, J. H. Park, R. S. Ahn et al., “Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha,” Molecular and Cellular Biology, vol. 24, no. 7, pp. 2593–2604, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. C. S. Ku, T. X. Pham, Y. Park et al., “Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes,” Biochimica et Biophysica Acta (BBA)—General Subjects, vol. 1830, no. 4, pp. 2981–2988, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. G. R. Dohle, M. Smit, and R. F. A. Weber, “Androgens and male fertility,” World Journal of Urology, vol. 21, no. 5, pp. 341–345, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Ai, A. Zarifkar, M. A. Takhshid, J. Alavi, and M. Moradzadeh, “The effect of thyroid activity on adult rat spermatogenesis,” Iranian Journal of Veterinary Research, University of Shiraz, vol. 8, no. 2, pp. 155–160, 2007. View at Google Scholar
  47. J. J. Buzzard, J. R. Morrison, M. K. O'Bryan, Q. Song, and N. G. Wreford, “Developmental expression of thyroid hormone receptors in the rat testis,” Biology of Reproduction, vol. 62, no. 3, pp. 664–669, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. R. J. Aitken, “Free radicals, lipid peroxidation and sperm function,” Reproduction, Fertility, and Development, vol. 7, no. 4, pp. 659–668, 1995. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Vernet, R. J. Aitken, and J. R. Drevet, “Antioxidant strategies in the epididymis,” Molecular and Cellular Endocrinology, vol. 216, no. 1, pp. 31–39, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Ramya, M. M. Misro, D. Sinha, and D. Nandan, “Sperm function and seminal oxidative stress as tools to identify sperm pathologies in infertile men,” Fertility and Sterility, vol. 93, no. 1, pp. 297–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. J. P. K. Rooney, “The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury,” Toxicology, vol. 234, no. 3, pp. 145–156, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. A. S. Prasad, B. Bao, F. W. J. Beck, O. Kucuk, and F. H. Sarkar, “Antioxidant effect of zinc in humans,” Free Radical Biology and Medicine, vol. 37, no. 8, pp. 1182–1190, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. M. I. Yousef, G. A. Abdallah, and K. I. Kamel, “Effect of ascorbic acid and vitamin E supplementation on semen quality and biochemical parameters of male rabbits,” Animal Reproduction Science, vol. 76, no. 1-2, pp. 99–111, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. M. A. Rezvanfar, R. A. Sadrkhanlou, A. Ahmadi et al., “Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stress,” Human and Experimental Toxicology, vol. 27, no. 12, pp. 901–910, 2008. View at Publisher · View at Google Scholar · View at Scopus