Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7962948, 12 pages
http://dx.doi.org/10.1155/2016/7962948
Research Article

Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice

1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China

Received 6 September 2016; Accepted 11 October 2016

Academic Editor: Ravirajsinh Jadeja

Copyright © 2016 Ruibing Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Qu, H. Xin, G. Zheng, Y. Su, and C. Ling, “Hepatoprotective activity of the total saponins from Actinidia valvata dunn root against carbon tetrachloride-induced liver damage in mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 216061, 13 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. R. N. Jadeja, N. H. Urrunaga, S. Dash, S. Khurana, and N. K. Saxena, “Withaferin-a reduces acetaminophen-induced liver injury in mice,” Biochemical Pharmacology, vol. 97, no. 1, pp. 122–132, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Dong, L. Xu, L. Yin, Y. Qi, and J. Peng, “Naringin prevents carbon tetrachloride-induced acute liver injury in mice,” Journal of Functional Foods, vol. 12, pp. 179–191, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Su, X. Xia, Q. Shi et al., “Neohesperidin dihydrochalcone versus CCl4-induced hepatic injury through different mechanisms: the implication of free radical scavenging and Nrf2 Activation,” Journal of Agricultural and Food Chemistry, vol. 63, no. 22, pp. 5468–5475, 2015. View at Publisher · View at Google Scholar
  5. A. F. Ismail, A. A. Salem, and M. M. Eassawy, “Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat,” Journal of Photochemistry and Photobiology B: Biology, vol. 160, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  6. G. M. Campo, A. Avenoso, S. Campo et al., “Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury,” Life Sciences, vol. 74, no. 10, pp. 1289–1305, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. B. O. Cho, H. W. Ryu, C. H. Jin et al., “Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats,” Journal of Agricultural and Food Chemistry, vol. 59, no. 21, pp. 11442–11448, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. Y.-F. Lu, J. Liu, K. C. Wu, Q. Qu, F. Fan, and C. D. Klaassen, “Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice,” PLoS ONE, vol. 9, no. 3, Article ID e93013, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Scorletti, L. Bhatia, K. G. Mccormick et al., “Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME study,” Hepatology, vol. 60, no. 4, pp. 1211–1221, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. E. M. Tillman and R. A. Helms, “Omega-3 long chain polyunsaturated Fatty acids for treatment of parenteral nutrition-associated liver disease: a review of the literature,” The Journal of Pediatric Pharmacology and Therapeutics, vol. 16, pp. 31–38, 2011. View at Google Scholar
  11. M. Wang, X. Zhang, C. Yan et al., “Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice,” Journal of Functional Foods, vol. 23, pp. 532–541, 2016. View at Publisher · View at Google Scholar
  12. M. Wang, X. Zhang, K. Feng et al., “Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice,” Scientific Reports, vol. 6, p. 26826, 2016. View at Publisher · View at Google Scholar
  13. L. L. Huang, J. B. Wan, B. Wang et al., “Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 88, no. 5, pp. 347–353, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Schmöcker, K. H. Weylandt, L. Kahlke et al., “Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines,” Hepatology, vol. 45, no. 4, pp. 864–869, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-B. Wan, L.-L. Huang, R. Rong, R. Tan, J. Wang, and J. X. Kang, “Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 12, pp. 2487–2494, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. J. X. Kang, J. Wang, L. Wu, and Z. B. Kang, “Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids,” Nature, vol. 427, no. 6974, p. 504, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Xu, T. Guo, Y.-F. Guo et al., “Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus,” Glycobiology, vol. 18, no. 1, pp. 97–103, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. X.-J. Zhang, L.-L. Huang, X.-J. Cai, P. Li, Y.-T. Wang, and J.-B. Wan, “Fatty acid variability in three medicinal herbs of Panax species,” Chemistry Central Journal, vol. 7, no. 1, article 12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. X.-J. Zhang, L.-L. Huang, H. Su et al., “Characterizing plasma phospholipid fatty acid profiles of polycystic ovary syndrome patients with and without insulin resistance using GC-MS and chemometrics approach,” Journal of Pharmaceutical and Biomedical Analysis, vol. 95, pp. 85–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. G.-J. Huang, J.-S. Deng, S.-S. Huang, Y.-Y. Shao, C.-C. Chen, and Y.-H. Kuo, “Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice,” Food Chemistry, vol. 132, no. 2, pp. 709–716, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. R.-B. Ding, K. Tian, L.-L. Huang et al., “Herbal medicines for the prevention of alcoholic liver disease: a review,” Journal of Ethnopharmacology, vol. 144, no. 3, pp. 457–465, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. R.-B. Ding, K. Tian, Y.-W. Cao et al., “Protective effect of Panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress,” Journal of Agricultural and Food Chemistry, vol. 63, no. 9, pp. 2413–2422, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. Y.-T. Tung, J.-H. Wu, C.-C. Huang et al., “Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats,” Food and Chemical Toxicology, vol. 47, no. 6, pp. 1385–1392, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. X.-J. Zhang, C. He, P. Li, H. Su, and J.-B. Wan, “Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage,” Journal of Functional Foods, vol. 15, pp. 580–592, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. H.-Y. Kim, J. Park, K.-H. Lee et al., “Ferulic acid protects against carbon tetrachloride-induced liver injury in mice,” Toxicology, vol. 282, no. 3, pp. 104–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. X. Kang, “Fat-1 transgenic mice: a new model for omega-3 research,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 77, no. 5-6, pp. 263–267, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. J.-C. Lin, Y.-J. Peng, S.-Y. Wang et al., “Sympathetic nervous system control of carbon tetrachloride-induced oxidative stress in liver through α-adrenergic signaling,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 3190617, 11 pages, 2016. View at Publisher · View at Google Scholar
  28. G. Ray and S. A. Husain, “Oxidants, antioxidants and carcinogenesis,” Indian Journal of Experimental Biology, vol. 40, no. 11, pp. 1213–1232, 2002. View at Google Scholar · View at Scopus
  29. M. Boll, L. W. Weber, E. Becker, and A. Stampfl, “Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites,” Zeitschrift für Naturforschung C, vol. 56, pp. 649–659, 2001. View at Google Scholar
  30. K. Aoyama and T. Nakaki, “Glutathione in cellular redox homeostasis: association with the excitatory amino acid carrier 1 (EAAC1),” Molecules, vol. 20, no. 5, pp. 8742–8758, 2015. View at Publisher · View at Google Scholar
  31. Y.-W. Cao, Y. Jiang, D.-Y. Zhang et al., “Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice,” Journal of Ethnopharmacology, vol. 161, pp. 92–98, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Taguchi, H. Motohashi, and M. Yamamoto, “Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution,” Genes to Cells, vol. 16, no. 2, pp. 123–140, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Chen, H. G. Shertzer, S. N. Schneider, D. W. Nebert, and T. P. Dalton, “Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels,” The Journal of Biological Chemistry, vol. 280, no. 40, pp. 33766–33774, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Karakus, A. Karadeniz, N. Simsek et al., “Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4),” Journal of Hazardous Materials, vol. 195, pp. 208–213, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. B.-Y. Yang, X.-Y. Zhang, S.-W. Guan, and Z.-C. Hua, “Protective effect of procyanidin B2 against CCl4-induced acute liver injury in mice,” Molecules, vol. 20, no. 7, pp. 12250–12265, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Kim, N. Jung, K. Lee et al., “Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts,” Clinical Nutrition, vol. 32, no. 5, pp. 855–862, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. D. M. Finucane, E. Bossy-Wetzel, N. J. Waterhouse, T. G. Cotter, and D. R. Green, “Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL,” The Journal of Biological Chemistry, vol. 274, no. 4, pp. 2225–2233, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. J.-Q. Ma, J. Ding, L. Zhang, and C.-M. Liu, “Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway,” Food and Chemical Toxicology, vol. 64, pp. 41–48, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. D. N. Dhanasekaran and E. P. Reddy, “JNK signaling in apoptosis,” Oncogene, vol. 27, no. 48, pp. 6245–6251, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. D.-I. Kim, S.-J. Lee, S.-B. Lee, K. Park, W.-J. Kim, and S.-K. Moon, “Requirement for Ras/Raf/ERK pathway in naringin-induced G1 -cell-cycle arrest via p21WAF1 expression,” Carcinogenesis, vol. 29, no. 9, pp. 1701–1709, 2008. View at Publisher · View at Google Scholar · View at Scopus