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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 8173876, 9 pages
Research Article

Euterpe edulis Extract but Not Oil Enhances Antioxidant Defenses and Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Rats

1Department of Biochemistry and Molecular Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil
2Department of Structural Biology, Federal University of Alfenas, 37130-000 Alfenas, MG, Brazil
3Department of Animal Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil
4School of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, 39100-000 Diamantina, MG, Brazil
5Department of Nutrition and Health, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil
6Department of Medicine and Nursing, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil

Received 13 April 2016; Revised 13 May 2016; Accepted 16 May 2016

Academic Editor: Salah A. Sheweita

Copyright © 2016 Rodrigo Barros Freitas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated the effects of E. edulis bioproducts (lyophilized pulp [LEE], defatted lyophilized pulp [LDEE], and oil [EO]) on nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in rats. All products were chemically analyzed. In vivo, 42 rats were equally randomized into seven groups receiving standard diet, HFD alone or combined with EO, LEE, or LDEE. After NAFLD induction, LEE, LDEE, or EO was added to the animals’ diet for 4 weeks. LEE was rich in polyunsaturated fatty acids. From LEE degreasing, LDEE presented higher levels of anthocyanins and antioxidant capacity in vitro. Dietary intake of LEE and especially LDEE, but not EO, attenuated diet-induced NAFLD, reducing inflammatory infiltrate, steatosis, and lipid peroxidation in liver tissue. Although both E. edulis bioproducts were not hepatotoxic, only LDEE presented sufficient benefits to treat NAFLD in rats, possibly by its low lipid content and high amount of phenols and anthocyanins.