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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 8715185, 11 pages
http://dx.doi.org/10.1155/2016/8715185
Research Article

Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats

1Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Road, Shanghai 200071, China
2Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital, 171 77 Stockholm, Sweden
3Center for Radiological Research, Department of Radiation Oncology, College of Physician and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA

Received 1 October 2016; Accepted 30 November 2016

Academic Editor: Mohamed M. Abdel-Daim

Copyright © 2016 Xuezhong Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. Keaney, C. M. Hannon, and P. T. Murray, “Contrast-induced acute kidney injury: how much contrast is safe?” Nephrology Dialysis Transplantation, vol. 28, no. 6, pp. 1376–1383, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Li, C. Wang, C. Liu, R. Li, M. Zou, and G. Cheng, “Efficacy of short-term statin treatment for the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography/percutaneous coronary intervention: a meta-analysis of 21 randomized controlled trials,” American Journal of Cardiovascular Drugs, vol. 16, no. 3, pp. 201–219, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. R. J. Owen, S. Hiremath, A. Myers, M. Fraser-Hill, and B. J. Barrett, “Canadian association of radiologists consensus guidelines for the prevention of contrast-induced nephropathy: update 2012,” Canadian Association of Radiologists Journal, vol. 65, no. 2, pp. 96–105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Rear, R. M. Bell, and D. J. Hausenloy, “Contrast-induced nephropathy following angiography and cardiac interventions,” Heart, vol. 102, no. 8, pp. 638–648, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. R. M. Bell, R. Rear, J. Cunningham, A. Dawnay, and D. M. Yellon, “Effect of remote ischaemic conditioning on contrast-induced nephropathy in patients undergoing elective coronary angiography (ERICCIN): rationale and study design of a randomised single-centre, double-blind placebo-controlled trial,” Clinical Research in Cardiology, vol. 103, no. 3, pp. 203–209, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Gong, G. Celsi, K. Carlsson, S. Norgren, and M. Chen, “N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling,” American Journal of Nephrology, vol. 31, no. 2, pp. 178–188, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Gong, Q. Wang, X. Tang et al., “Tetramethylpyrazine prevents contrast-induced nephropathy by inhibiting p38 MAPK and FoxO1 signaling pathways,” American Journal of Nephrology, vol. 37, no. 3, pp. 199–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. T. B. Sterenborg, T. P. Menting, Y. de Waal et al., “Remote ischemic preconditioning to reduce contrast-induced nephropathy: study protocol for a randomized controlled trial,” Trials, vol. 15, article 119, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. J. A. Neyra, S. Shah, R. Mooney, G. Jacobsen, J. Yee, and J. E. Novak, “Contrast-induced acute kidney injury following coronary angiography: a cohort study of hospitalized patients with or without chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 28, no. 6, pp. 1463–1471, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Kooiman, Y. W. J. Sijpkens, J.-P. P. M. De Vries et al., “A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography,” Nephrology Dialysis Transplantation, vol. 29, no. 5, pp. 1029–1036, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Lameire, J. A. Kellum, P. Aspelin et al., “Contrast-induced acute kidney injury and renal support for acute kidney injury: a KDIGO summary (part 2),” Critical Care, vol. 17, no. 1, article 205, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. K. A. Carver and D. Yang, “N-acetylcysteine amide protects against oxidative stress–induced microparticle release from human retinal pigment epithelial cells,” Investigative Ophthalmology and Visual Science, vol. 57, no. 2, pp. 360–371, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Paul, M. Hemshekhar, R. M. Thushara et al., “Methotrexate promotes platelet apoptosis via JNK-mediated mitochondrial damage: alleviation by N-acetylcysteine and N-acetylcysteine amide,” PLoS ONE, vol. 10, no. 6, Article ID e0127558, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Benterud, M. B. Ystgaard, S. Manueldas et al., “N-acetylcysteine amide exerts possible neuroprotective effects in newborn pigs after perinatal asphyxia,” Neonatology, vol. 111, no. 1, pp. 12–21, 2016. View at Publisher · View at Google Scholar
  15. K. Sunitha, M. Hemshekhar, R. M. Thushara et al., “N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine,” Free Radical Research, vol. 47, no. 5, pp. 357–367, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Gong, G. Celsi, K. Carlsson, and S. Norgren, “Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells,” Renal Failure, vol. 34, no. 4, pp. 487–494, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Andreucci, G. Lucisano, T. Faga et al., “Differential activation of signaling pathways involved in cell death, survival and inflammation by radiocontrast media in human renal proximal tubular cells,” Toxicological Sciences, vol. 119, no. 2, pp. 408–416, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Quintavalle, M. Brenca, F. De Micco et al., “In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis,” Cell Death and Disease, vol. 2, no. 5, article no. e155, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Y. Ma, G. H. Tesch, and D. J. Nikolic-Paterson, “ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney,” American Journal of Physiology - Renal Physiology, vol. 307, no. 11, pp. F1263–F1273, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Y. Ma, G. H. Tesch, and D. J. Nikolic-Paterson, “ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney,” American Journal of Physiology—Renal Physiology, vol. 307, no. 11, pp. F1263–F1273, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Hao, T. Takano, J. Guillemette, J. Papillon, G. Ren, and A. V. Cybulsky, “Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38,” Journal of Biological Chemistry, vol. 281, no. 6, pp. 3075–3084, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. R. M. Hashem, K. M. Hassanin, L. A. Rashed, M. O. Mahmoud, and M. G. Hassan, “Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity,” Experimental Biology and Medicine, vol. 241, no. 11, pp. 1250–1257, 2016. View at Publisher · View at Google Scholar
  23. Q.-Q. Wu, M. Xu, Y. Yuan et al., “Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 308, no. 9, pp. H1143–H1154, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Huang, L. Wu, J. Wu, Y. Li, and L. Hou, “Cellular FLICE-like inhibitory protein protects against cardiac hypertrophy by blocking ASK1/p38 signaling in mice,” Molecular and Cellular Biochemistry, vol. 397, no. 1-2, pp. 87–95, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Shen, F. Lu, J. Xie et al., “Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics,” Oncotarget, vol. 7, no. 31, pp. 50596–50611, 2016. View at Publisher · View at Google Scholar
  26. R. Jin, Y. Gao, S. Zhang et al., “Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities,” Immunology and Cell Biology, vol. 93, no. 8, pp. 744–752, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Agmon, H. Peleg, Z. Greenfeld, S. Rosen, and M. Brezis, “Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat,” Journal of Clinical Investigation, vol. 94, no. 3, pp. 1069–1075, 1994. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Yokomaku, T. Sugimoto, S. Kume et al., “Asialoerythropoietin prevents contrast-induced nephropathy,” Journal of the American Society of Nephrology, vol. 19, no. 2, pp. 321–328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. H. T. Lee, M. Jan, C. B. Soo et al., “A1 adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo,” American Journal of Physiology—Renal Physiology, vol. 290, no. 6, pp. F1367–F1375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. X. Gong, V. N. Ivanov, and T. K. Hei, “2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells,” Archives of Toxicology, vol. 90, no. 9, pp. 2187–2200, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Gong, V. N. Ivanov, M. M. Davidson, and T. K. Hei, “Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death,” Archives of Toxicology, vol. 89, no. 7, pp. 1057–1070, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Tongqiang, L. Shaopeng, Y. Xiaofang et al., “Salvianolic acid B prevents iodinated contrast media-induced acute renal injury in rats via the PI3K/Akt/Nrf2 pathway,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 7079487, 11 pages, 2016. View at Publisher · View at Google Scholar
  33. M. Buyuklu, F. M. Kandemir, M. Ozkaraca, T. Set, E. M. Bakirci, and E. Topal, “Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis?” European Review for Medical and Pharmacological Sciences, vol. 18, no. 4, pp. 461–470, 2014. View at Google Scholar · View at Scopus
  34. A. Tasanarong, S. Kongkham, and A. Itharat, “Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury,” BMC Complementary and Alternative Medicine, vol. 14, article 138, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Wang, R.-B. Wei, Q.-P. Li et al., “Renal protective effect of probucol in rats with contrast-induced nephropathy and its underlying mechanism,” Medical Science Monitor, vol. 21, pp. 2886–2892, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Lichosik, A. Jung, K. Jobs, A. Mierzejewska, R. Zdanowski, and B. Kalicki, “Interleukin 18 and neutrophil-gelatinase associated lipocalin in assessment of the risk of contrast-induced nephropathy in children,” Central European Journal of Immunology, vol. 40, no. 4, pp. 447–453, 2016. View at Publisher · View at Google Scholar · View at Scopus
  37. G. F. Lehner, L. G. Forni, and M. Joannidis, “Oliguria and biomarkers of acute kidney injury: star struck lovers or strangers in the night?” Nephron, vol. 134, no. 3, pp. 183–190, 2016. View at Publisher · View at Google Scholar
  38. S. S. Waikar and J. V. Bonventre, “Creatinine kinetics and the definition of acute kidney injury,” Journal of the American Society of Nephrology, vol. 20, no. 3, pp. 672–679, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Marcelino, I. Tavares, D. Carvalho et al., “Is urinary γ-glutamyl transpeptidase superior to urinary neutrophil gelatinase-associated lipocalin for early prediction of acute kidney injury after liver transplantation?” Transplantation Proceedings, vol. 46, no. 6, pp. 1812–1818, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. K. H. Shu, C. Wang, C. Wu et al., “Urinary π-glutathione S-transferase predicts advanced acute kidney injury following cardiovascular surgery,” Scientific Reports, vol. 6, article 26335, 2016. View at Publisher · View at Google Scholar
  41. A. Ray, N. Sehgal, S. Karunakaran, G. Rangarajan, and V. Ravindranath, “MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model,” Free Radical Biology and Medicine, vol. 87, Article ID 12501, pp. 312–325, 2015. View at Publisher · View at Google Scholar · View at Scopus