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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 9124676, 8 pages
Research Article

Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients

1Research Unit, Primary Care Centre La Alamedilla, SACYL, Avenida de los Comuneros 27, 37003 Salamanca, Spain
2Institute of Biomedical Research of Salamanca (IBSAL), Renal and Cardiovascular Pathophysiology Unit, Department of Physiology and Pharmacology, University of Salamanca, Avenida Campo Charro s/n, 37007 Salamanca, Spain
3Institute of Studies in Health Sciences of Castilla y León (IECSCYL), Research Unit, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain

Received 17 February 2015; Revised 9 June 2015; Accepted 14 June 2015

Academic Editor: Matías Mosqueira

Copyright © 2016 Manuel A. Gómez-Marcos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress is associated with cardiac and vascular defects leading to hypertension and atherosclerosis, being superoxide dismutase (SOD) one of the main intracellular antioxidant defence mechanisms. Although several parameters of vascular function and structure have a predictive value for cardiovascular morbidity-mortality in hypertensive patients, there are no studies on the involvement of SOD serum levels with these vascular parameters. Thus, we assessed if SOD serum levels are correlated with parameters of vascular function and structure and with cardiovascular risk in hypertensive and type 2 diabetic patients. We enrolled 255 consecutive hypertensive and diabetic patients and 52 nondiabetic and nonhypertensive controls. SOD levels were measured with an enzyme-linked immunosorbent assay kit. Vascular function and structure were evaluated by pulse wave velocity, augmentation index, ambulatory arterial stiffness index, and carotid intima-media thickness. We detected negative correlations between SOD and pressure wave velocity, peripheral and central augmentation index and ambulatory arterial stiffness index, pulse pressure, and plasma HDL-cholesterol, as well as positive correlations between SOD and plasma uric acid and triglycerides. Our study shows that SOD is a marker of cardiovascular alterations in hypertensive and diabetic patients, since changes in its serum levels are correlated with alterations in vascular structure and function.