Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage

Figure 7

Effect of changing direction of flow rate on enzyme release from isolated livers of control and PH rats. Results of enzyme activities are expressed as mean ± SE (six independent determinations per experimental point) of times over a baseline flow rate of 1 mL⋅min⁻¹⋅g⁻¹ of liver for LDH, ALT, GDH, and OCT, in sham-operated and 70%-PH animals. Enzyme activities were measured in the perfusates from portal (empty) or cava (solid symbols) veins, under equal liver perfusion conditions to those shown in Figure 1.

(a) Controls

(b) Hepatectomized