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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 1406726, 13 pages
https://doi.org/10.1155/2017/1406726
Research Article

Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide

1Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China
2Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
3State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
4Department of Pathology, School of Medicine, Saint Louis University, Saint Louis, MO 63104, USA

Correspondence should be addressed to Shizhong Zheng; moc.361@mcungnehzs

Received 31 July 2016; Revised 22 December 2016; Accepted 30 January 2017; Published 20 February 2017

Academic Editor: Ranjitsinh Devkar

Copyright © 2017 Feng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. L. Friedman, “Evolving challenges in hepatic fibrosis,” Nature Reviews. Gastroenterology & Hepatology, vol. 7, no. 8, pp. 425–436, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Tacke and R. Weiskirchen, “Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques,” Expert Review of Gastroenterology & Hepatology, vol. 6, no. 1, pp. 67–80, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Sánchez-Valle, N. C. Chávez-Tapia, M. Uribe, and N. Méndez-Sánchez, “Role of oxidative stress and molecular changes in liver fibrosis: a review,” Current Medicinal Chemistry, vol. 19, no. 28, pp. 4850–4860, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Zhang, C. Ni, D. Kong et al., “Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways,” Toxicology and Applied Pharmacology, vol. 265, no. 1, pp. 51–60, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. M. S. Butt, M. T. Sultan, M. S. Butt, and J. Iqbal, “Garlic: nature's protection against physiological threats,” Critical Reviews in Food Science and Nutrition, vol. 49, no. 6, pp. 538–551, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Ariga and T. Seki, “Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review,” BioFactors, vol. 26, no. 2, pp. 93–103, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Zhu, F. Zhang, L. Zhou et al., “Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 387, no. 5, pp. 445–455, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Fiorucci, E. Distrutti, G. Cirino, and J. L. Wallace, “The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver,” Gastroenterology, vol. 131, no. 1, pp. 259–271, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. J. Norris, C. R. Culberson, S. Narasimhan, and M. G. Clemens, “The liver as a central regulator of hydrogen sulfide,” Shock, vol. 36, no. 3, pp. 242–250, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Oya-Ohta, T. Ochi, Y. Komoda, and K. Yamamoto, “The biological activity of hydrogen peroxide. VI. Mechanism of the enhancing effects of l-histidine: the role of the formation of a histidine-peroxide adduct and membrane transport,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 326, no. 1, pp. 99–107, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. G. A. Benavides, G. L. Squadrito, R. W. Mills et al., “Hydrogen sulfide mediates the vasoactivity of garlic,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 46, pp. 17977–17982, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Zhang, F. Zhang, D. Kong et al., “Tetramethylpyrazine inhibits angiotensin II-induced activation of hepatic stellate cells associated with interference of platelet-derived growth factor β receptor pathways,” FEBS Journal, vol. 281, no. 12, pp. 2754–2768, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. G. D'Argenio, D. C. Amoruso, G. Mazzone et al., “Garlic extract prevents CCl4-induced liver fibrosis in rats: the role of tissue transglutaminase,” Digestive and Liver Disease, vol. 42, no. 8, pp. 571–577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Gedik, L. Kabasakal, Ö. Şehirli et al., “Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats,” Life Sciences, vol. 76, no. 22, pp. 2593–2606, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Mani, W. Cao, L. Wu, and R. Wang, “Hydrogen sulfide and the liver,” Nitric Oxide, vol. 41, pp. 62–71, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Tan, S. Pan, J. Li et al., “Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats,” PLoS ONE, vol. 6, no. 10, Article ID e25943, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. H.-N. Fan, H.-J. Wang, L. Ren et al., “Decreased expression of p38 MAPK mediates protective effects of hydrogen sulfide on hepatic fibrosis,” European Review for Medical and Pharmacological Sciences, vol. 17, no. 5, pp. 644–652, 2013. View at Google Scholar · View at Scopus
  18. H. N. Fan, H. J. Wang, C. R. Yang-Dan et al., “Protective effects of hydrogen sulfide on oxidative stress and fibrosis in hepatic stellate cells,” Molecular Medicine Reports, vol. 7, no. 1, pp. 247–253, 2013. View at Google Scholar
  19. G. Yang, L. Wu, and R. Wang, “Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells,” The FASEB Journal, vol. 20, no. 3, pp. 553–555, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Wang, J. Han, L. Xiao, C.-E. Jin, D.-J. Li, and Z. Yang, “Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease,” World Journal of Gastroenterology, vol. 20, no. 4, pp. 1079–1087, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Kang, M. Zhao, H. Jiang, G. Tan, S. Pan, and X. Sun, “Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats,” Liver Transplantation, vol. 15, no. 10, pp. 1306–1314, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. K.-C. Lai, S.-C. Hsu, J.-S. Yang, C.-C. Yu, J.-C. Lein, and J.-G. Chung, “Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth,” Journal of Cellular and Molecular Medicine, vol. 19, no. 2, pp. 474–484, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Chandra-Kuntal, J. Lee, and S. V. Singh, “Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic,” Breast Cancer Research and Treatment, vol. 138, no. 1, pp. 69–79, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Weiskirchen and F. Tacke, “Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology,” Hepatobiliary Surgery and Nutrition, vol. 3, no. 6, pp. 344–363, 2014. View at Google Scholar
  25. M. Whiteman, L. Li, P. Rose, C.-H. Tan, D. B. Parkinson, and P. K. Moore, “The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages,” Antioxidants and Redox Signaling, vol. 12, no. 10, pp. 1147–1154, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Kimura, Y.-I. Goto, and H. Kimura, “Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria,” Antioxidants & Redox Signaling, vol. 12, no. 1, pp. 1–13, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Jha, J. W. Calvert, M. R. Duranski, A. Ramachandran, and D. J. Lefer, “Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 295, no. 2, pp. H801–H806, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. N. N. Osborne, D. Ji, A. S. A. Majid, R. J. Fawcett, A. Sparatore, and P. Del Soldato, “ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture,” Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 284–294, 2010. View at Publisher · View at Google Scholar · View at Scopus