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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 1583098, 10 pages
https://doi.org/10.1155/2017/1583098
Research Article

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats

1Division of Biology, Faculty of Science, Firat University, Elazig, Turkey
2Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
3Research and Development, OmniActive Health Technologies Inc., Morristown, NJ, USA

Correspondence should be addressed to Kazim Sahin; moc.oohay@mknihasn

Received 13 January 2017; Accepted 26 February 2017; Published 15 March 2017

Academic Editor: Jasminka Giacometti

Copyright © 2017 Zeynep Tuzcu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile () and reduced serum and liver MDA concentration compared to HFD rats (). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.