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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 1910450, 8 pages
https://doi.org/10.1155/2017/1910450
Research Article

Ghrelin Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Damage

1Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, Harbin, China
2Public Department, Second Affiliated Hospital, Harbin Medical University, Harbin, China

Correspondence should be addressed to Yi Zheng; moc.361@yttikgnehziy

Received 23 February 2017; Revised 18 April 2017; Accepted 23 April 2017; Published 10 October 2017

Academic Editor: Grzegorz Bartosz

Copyright © 2017 Jie Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxidative stress has been recognized as an important mediator in the pathogenesis of age-related cataracts; using antioxidant supplements is one plausible strategy to protect the antioxidative defense system against oxidative stress. Ghrelin administration is expected to reduce ROS, preventing the onset of different diseases. The role of ghrelin, if any, in protecting against oxidative stress in HLECs has never been examined. In the present study, we investigated the effects of ghrelin against H2O2-induced oxidative stress and the associated molecular mechanisms in HLECs and rat lenses. The results showed that pretreatment with ghrelin reduced H2O2-induced cellular apoptosis and ROS accumulation, increased the expression levels of SOD and CAT, and decreased the expression level of MDA. The morphological examination showed that the ghrelin-treated lens organ culture maintained transparency. This is the first report to show that ghrelin can protect HLECs from H2O2-induced oxidative stress. Our findings suggest that ghrelin may prevent the progression of cataracts, which has treatment value for ophthalmologists.