Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint

<div>MAD2L1 expression is induced in mouse zygotes following treatment with 0.03 mM H<sub>2</sub>O<sub>2</sub>. MAD2L1 immunofluorescence (green) was undetected in untreated cells but detected following treatment of zygotes with H<sub>2</sub>O<sub>2</sub>. Nuclei (blue) were stained with DAPI.</div>

Oxidative Medicine and Cellular Longevity

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Figure 5

Figure 5: Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint 