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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 2383157, 10 pages
https://doi.org/10.1155/2017/2383157
Research Article

Radical Scavenger Capacity of Jabuticaba Fruit (Myrciaria cauliflora) and Its Biological Effects in Hypertensive Rats

1Faculty of Pharmacy, Federal University of Goiás, Avenida Universitária s/n, 74605-220 Goiânia, GO, Brazil
2Unit of Exact and Technological Sciences, State University of Goiás, Caixa Postal 459, 75132-903 Anápolis, GO, Brazil
3School of Medical, Pharmaceutical and Biomedical Sciences, Pontifical Catholic University of Goiás, 74605-010 Goiânia, GO, Brazil
4Institute of Chemistry, Federal University of Goiás, Campus Samambaia, Caixa Postal 131, 74001-970 Goiânia, GO, Brazil

Correspondence should be addressed to Matheus Lavorenti Rocha; rb.moc.oohay@hcorsuehtam

Received 11 July 2017; Accepted 30 October 2017; Published 20 December 2017

Academic Editor: Maria S. Alves

Copyright © 2017 Camila Gabriela de Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Jabuticaba is an exotic fruit native to Brazil that has been arousing medicinal interest. Using chemical (HPLC-PDA, resonance mass spectra, and NMR), electroanalytical (differential pulse voltammetry, radical scavenging assay), and pharmacological (in vivo and in vitro) approaches, we have identified its bioactive compounds and hypotensive effects on hypertensive rats. The hydroalcoholic extract of jabuticaba (HEJ) presents a great quantity of phenolic compounds, and several molecules with hydroxyl groups present high efficiency as an antioxidant. The treatment with HEJ (100 and 300 mg/kg/day, for four weeks) presented hypotensive effects on L-NAME-induced hypertensive rats, possibly improving the nitric oxide bioavailability because of its high antioxidant potential. Furthermore, renal and cardiac hypertrophies were also attenuated after the HEJ treatment. Moreover, the vascular responses to contractile and dilating agonists were improved with the HEJ treatment, which is also able to induce nitric oxide production in endothelial cells.