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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 2578950, 12 pages
https://doi.org/10.1155/2017/2578950
Research Article

Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes

1School of Nursing of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
2Department of Mathematics, Federal University of Technology-Paraná (UTFPR), Avenida Alberto Carazzai, 1640, 86300-000 Cornélio Procópio, PR, Brazil
3School of Medicine of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
4School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
5Department of Physical Education, School of Science, São Paulo State University (UNESP), Avenida Engenheiro Luiz Edmundo Carrijo Coube, 14-01, Bairro Vargem Limpa, 17033-360 Bauru, SP, Brazil

Correspondence should be addressed to Atila Alexandre Trapé; rb.psu@eparta

Received 13 April 2017; Revised 24 July 2017; Accepted 6 August 2017; Published 14 September 2017

Academic Editor: Vitor A. Lira

Copyright © 2017 Atila Alexandre Trapé et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to verify the influence of the genotype or haplotype (interaction) of the NOS3 polymorphisms [-786T>C, 894G>T (Glu298Asp), and intron 4b/a] on the response to multicomponent training (various capacities and motor skills) on blood pressure (BP), nitrite concentration, redox status, and physical fitness in older adult women. The sample consisted of 52 participants, who underwent body mass index and BP assessments. Physical fitness was evaluated by six-minute walk, elbow flexion, and sit and stand up tests. Plasma/blood samples were used to evaluate redox status, nitrite concentration, and genotyping. Associations were observed between isolated polymorphisms and the response of decreased systolic and diastolic BP and increased nitrite concentration and antioxidant activity. In the haplotype analysis, the group composed of ancestral alleles (H1) was the only one to present improvement in all variables studied (decrease in systolic and diastolic BP, improvement in nitrite concentration, redox status, and physical fitness), while the group composed of variant alleles (H8) only demonstrated improvement in some variables of redox status and physical fitness. These findings suggest that NOS3 polymorphisms and physical training are important interacting variables to consider in evaluating redox status, nitric oxide availability and production, and BP control.