Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 2578950, 12 pages
https://doi.org/10.1155/2017/2578950
Research Article

Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes

1School of Nursing of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
2Department of Mathematics, Federal University of Technology-Paraná (UTFPR), Avenida Alberto Carazzai, 1640, 86300-000 Cornélio Procópio, PR, Brazil
3School of Medicine of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
4School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
5Department of Physical Education, School of Science, São Paulo State University (UNESP), Avenida Engenheiro Luiz Edmundo Carrijo Coube, 14-01, Bairro Vargem Limpa, 17033-360 Bauru, SP, Brazil

Correspondence should be addressed to Atila Alexandre Trapé; rb.psu@eparta

Received 13 April 2017; Revised 24 July 2017; Accepted 6 August 2017; Published 14 September 2017

Academic Editor: Vitor A. Lira

Copyright © 2017 Atila Alexandre Trapé et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. UNFPA – United Nations Population Fund, Ageing in the twenty-First Century: A Celebration and a Challenge, Nova York, USA, 2012, http://www.unfpa.org/sites/default/files/pub-pdf/Ageing%20report.pdf.
  2. S. I. S. Rattan, “Aging is not a disease: implications for intervention,” Aging and Disease, vol. 5, no. 3, pp. 196–202, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. American College of Sports Medicine, W. J. Chodzko-Zajko, D. N. Proctor et al., “American College of Sports Medicine position stand: exercise and physical activity for older adults,” Medicine and Science in Sports and Exercise, vol. 41, no. 7, pp. 1510–1530, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. V. B. Malachias, W. K. S. B. de Souza, F. L. Plavnik et al., “VII Diretriz Brasileira de Hipertensão Arterial,” Arquivos Brasileiros de Cardiologia, vol. 107, Supplement 3, no. 3, pp. 1–83, 2016. View at Google Scholar
  5. B. J. North and D. A. Sinclair, “The intersection between aging and cardiovascular disease,” Circulation Research, vol. 110, no. 8, pp. 1097–1108, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. L. M. Neves, T. A. Diniz, F. E. Rossi et al., “The effect of different training modalities on physical fitness in women over 50 year of age,” Motriz, vol. 22, no. 4, pp. 319–326, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. C. E. Garber, B. Blissmer, M. R. Deschenes et al., “Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise,” Medicine and Science in Sports and Exercise, vol. 43, no. 7, pp. 1334–1359, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Parati, J. E. Ochoa, C. Lombardi, and G. Bilo, “Assessment and management of blood-pressure variability,” Nature Reviews Cardiology, vol. 10, pp. 143–155, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Jacomini, H. C. de Souza, S. Dias Dda et al., “Training status as a marker of the relationship between nitric oxide, oxidative stress, and blood pressure in older adult women,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8262383, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Modun, D. Giustarini, and D. Tsikas, “Nitric oxide-related oxidative stress and redox status in health and disease,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 129651, 3 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Moncada and E. A. Higgs, “The discovery of nitric oxide and its role in vascular biology,” British Journal of Pharmacology, vol. 147, Supplement 1, pp. S192–S201, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. J. W. E. Rush, H. J. Green, D. A. MacLean, and L. M. Code, “Oxidative stress and nitric oxide synthase in skeletal muscles of rats with post-infarction, compensated chronic heart failure,” Acta Physiologica Scandinavica, vol. 185, no. 3, pp. 211–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. P. M. Vanhoutte, “Endothelial control of vasomotor function – from health to coronary disease,” Circulation Journal, vol. 67, no. 7, pp. 572–575, 2003. View at Publisher · View at Google Scholar
  14. A. A. Trape, A. M. Jacomini, J. J. Muniz et al., “The relationship between training status, blood pressure and uric acid in adults and elderly,” BMC Cardiovascular Disorders, vol. 13, no. 1, p. 44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. R. F. da Silva, J. T. Sertório, R. Lacchini et al., “Influence of training status and eNOS haplotypes on plasma nitrite concentration in normotensive older adults: a hypothesis-generating study,” Aging Clinical and Experimental Research, vol. 26, no. 6, pp. 591–598, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. R. D. Esposti, C. H. G. Sponton, P. A. Malagrino et al., “Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women,” Brazilian Journal of Medical and Biological Research, vol. 44, no. 9, pp. 855–863, 2011. View at Google Scholar
  17. C. H. Sponton, R. Esposti, C. M. Rodovalho et al., “The presence of the NOS3 gene polymorphism for intron 4 mitigates the beneficial effects of exercise training on ambulatory blood pressure monitoring in adults,” American Journal of Physiology Heart and Circulatory Physiology, vol. 306, no. 12, pp. H1679–H1691, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Bouchard, L. M. Antunes-Correa, E. A. Ashley et al., “Personalized preventive medicine: genetics and the response to regular exercise in preventive interventions,” Progress in Cardiovascular Diseases, vol. 57, no. 4, pp. 337–346, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Karasik and A. Newman, “Models to explore genetics of human aging,” Longevity Genes – Advances in Experimental Medicine and Biology, vol. 847, pp. 141–161, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. J. P. Casas, G. L. Cavalleri, L. E. Bautista, L. Smeeth, S. E. Humphries, and A. D. Hingorani, “Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review,” American Journal of Epidemiology, vol. 164, no. 10, pp. 921–935, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. T. V. Pereira, M. Rudnick, B. M. Cheung et al., “Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias,” Journal of Hypertension, vol. 25, no. 9, pp. 1763–1774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Zintzaras, G. Kitsios, and I. Stefanidis, “Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis,” Hypertension, vol. 48, no. 4, pp. 700–710, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Borg and B. J. Noble, “Perceived exertion,” in Exercise and Sport Sciences Reviews, J. H. Wilmore, Ed., pp. 131–153, Academic Press, 2. ed edition, 1954. View at Google Scholar
  24. S. Matsudo, T. Araujo, V. Matsudo et al., “Questionário Internacional de Atividade Física (I-PAQ): estudo de validade e reprodutibilidade no Brasil,” Revista Atividade Física & Saúde, vol. 6, no. 2, pp. 5–18, 2001. View at Google Scholar
  25. Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica, Protocolos do Sistema de Vigilância Alimentar e Nutricional - SISVAN/Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica - Ministério da Saúde, Brasília, 2008.
  26. Abep. Associação Brasileira de Empresas de Pesquisa, Critério de classificação econômica Brasil, Belo Horizonte, 2008.
  27. R. E. Rikli and J. C. Jones, Teste de aptidão física para idosos, Manole, 2008.
  28. L. C. Pinheiro, M. F. Montenegro, J. H. Amaral, G. C. Ferreira, A. M. Oliveira, and J. E. Tanus-Santos, “Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats,” Free Radical Biology & Medicine, vol. 53, no. 4, pp. 701–709, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. Q. Fan, L. Chen, S. Cheng et al., “Aging aggravates nitrate-mediated ROS/RNS changes,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 376515, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Gerard-Monnier, I. Erdelmeier, K. Regnard, N. Moze-Henry, J. C. Yadan, and J. Chaudiere, “Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation,” Chemical Research in Toxicology, vol. 11, no. 10, pp. 1176–1183, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Ekstrom, P. Garberg, B. Egestad, and J. Hugberg, “Recovery of malondialdehyde in urine as a 2,4-dinitropjenylhydrazine derivate analyzed with high-performance liquid chromatography,” Chemico-Biological Interactions, vol. 66, no. 3-4, pp. 177–187, 1988. View at Publisher · View at Google Scholar · View at Scopus
  32. O. Erel, “A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation,” Clinical Biochemistry, vol. 37, no. 4, pp. 277–285, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. C. M. Costa, R. C. C. Santos, and E. S. Lima, “A simple automated procedure for thiol measurement in human serum samples,” Jornal Brasileiro de Patologia e Medicina Laboratorial, vol. 42, no. 5, pp. 345–350, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. D. K. Lahiri and J. I. Nurnberger Jr., “A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies,” Nucleic Acids Research, vol. 19, no. 19, p. 5444, 1991. View at Google Scholar
  35. V. Vasconcellos, R. Lacchini, A. L. Jacob-Ferreira et al., “Endothelial nitric oxide synthase haplotypes associated with hypertension do not predispose to cardiac hypertrophy,” DNA and Cell Biology, vol. 29, no. 4, pp. 171–176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. A. S. Zago, J. Y. Park, N. Fenty-Stewart, E. Kokubun, and M. D. Brown, “Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people,” European Journal Applied Physiology, vol. 110, no. 4, pp. 825–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. A. S. Marroni, I. F. Metzger, D. C. Souza-Costa et al., “Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms,” Nitric Oxide, vol. 12, no. 3, pp. 177–182, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Schall, “Estimation in generalized linear models with random effects,” Biometrika, vol. 78, no. 4, pp. 719–727, 1991. View at Publisher · View at Google Scholar · View at Scopus
  39. H. A. Santana, S. R. Moreira, R. Y. Asano et al., “Exercise intensity modulates nitric oxide and blood pressure responses in hypertensive older women,” Aging Clinical and Experimental Research, vol. 25, no. 1, pp. 43–48, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. B. M. Silva, F. J. Neves, N. G. Rocha et al., “Endothelial nitric oxide gene haplotype reduces the effect of a single bout of exercise on the vascular reactivity in healthy subjects,” Translational Research, vol. 161, no. 1, pp. 15–25, 2013. View at Publisher · View at Google Scholar · View at Scopus