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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 3064016, 15 pages
https://doi.org/10.1155/2017/3064016
Research Article

Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence

1Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Georg-August-Universität Göttingen, Universitätsmedizin Göttingen, Göttingen, Germany
2Zentrum Physiologie und Pathophysiologie, Institut für Neuro- und Sinnesphysiologie, Humboldtallee, 23 Göttingen, Germany

Correspondence should be addressed to Michael Müller; ed.gdwg@7elleumm

Received 15 March 2017; Revised 16 June 2017; Accepted 27 June 2017; Published 13 August 2017

Academic Editor: Icksoo Lee

Copyright © 2017 Dörthe F. Bebensee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Donatella Degl'Innocenti, Matteo Becatti, Marta Peruzzi, Claudia Fiorillo, Matteo Ramazzotti, Niccolò Nassi, Cinzia Arzilli, and Raffaele Piumelli, “Systemic oxidative stress in congenital central hypoventilation syndrome,” European Respiratory Journal, vol. 52, no. 5, pp. 1801497, 2018. View at Publisher · View at Google Scholar
  • Akshata Almad, and Nicholas J. Maragakis, “A stocked toolbox for understanding the role of astrocytes in disease,” Nature Reviews Neurology, 2018. View at Publisher · View at Google Scholar
  • Uri Kahanovitch, Kelsey C. Patterson, Raymundo Hernandez, and Michelle L. Olsen, “Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome,” International Journal of Molecular Sciences, vol. 20, no. 15, pp. 3813, 2019. View at Publisher · View at Google Scholar
  • Karolina Can, Christiane Menzfeld, Lena Rinne, Peter Rehling, Sebastian Kügler, Gocha Golubiani, Jan Dudek, and Michael Müller, “Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release,” Frontiers in Physiology, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Shashank Shrishrimal, Elizabeth A. Kosmacek, and Rebecca E. Oberley-Deegan, “Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–27, 2019. View at Publisher · View at Google Scholar
  • Michael Müller, “Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome,” Neuroscience & Biobehavioral Reviews, 2019. View at Publisher · View at Google Scholar