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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 4386947, 16 pages
Research Article

Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells

1Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 267/2, 61137 Brno, Czech Republic
2Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 2590/135, 61200 Brno, Czech Republic
3International Clinical Research Center, Centre of Biomolecular and Cellular Engineering, St. Anne’s University Hospital, Pekařská 53, 65691 Brno, Czech Republic

Correspondence should be addressed to Jiří Pacherník; zc.inum.ics@apij

Received 18 January 2017; Revised 27 April 2017; Accepted 15 May 2017; Published 27 July 2017

Academic Editor: Magdalena Skonieczna

Copyright © 2017 Jan Kučera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • You Zhou, Mingcai Zhao, Zheyan Pu, Guoqiang Xu, and Xiangkun Li, “Relationship between oxidative stress and inflammation in hyperuricemia,” Medicine, vol. 97, no. 49, pp. e13108, 2018. View at Publisher · View at Google Scholar
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  • Kateřina Štefková, Markéta Hanáčková, Jan Kučera, Katarzyna Anna Radaszkiewicz, Barbora Ambrůžová, Lukáš Kubala, and Jiří Pacherník, “MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells,” Stem Cells International, vol. 2019, pp. 1–16, 2019. View at Publisher · View at Google Scholar
  • Ismail Suliman Elgenaidi, and James Paul Spiers, “Hypoxia modulates protein phosphatase 2A through HIF‐1α dependent and independent mechanisms in human aortic smooth muscle cells and ventricular cardiomyocytes,” British Journal of Pharmacology, 2019. View at Publisher · View at Google Scholar
  • Zdena Moosova, Michaela Pekarova, Lenka Svihalkova Sindlerova, Ondrej Vasicek, Lukas Kubala, Ludek Blaha, and Ondrej Adamovsky, “Immunomodulatory effects of cyanobacterial toxin cylindrospermopsin on innate immune cells,” Chemosphere, 2019. View at Publisher · View at Google Scholar
  • I. Elgenaidi, and J.P. Spiers, “Regulation of the Phosphoprotein Phosphatase 2A System and its Modulation during Oxidative Stress: A Potential Therapeutic Target?,” Pharmacology & Therapeutics, 2019. View at Publisher · View at Google Scholar
  • John Canfield, Sefa Arlier, Ezinne F. Mong, John Lockhart, Jeffrey VanWye, Ozlem Guzeloglu-Kayisli, Frederick Schatz, Ronald R. Magness, Charles J. Lockwood, John C. M. Tsibris, Umit A. Kayisli, and Hana Totary-Jain, “Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration,” The FASEB Journal, vol. 33, no. 2, pp. 2759–2769, 2019. View at Publisher · View at Google Scholar