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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 5032102, 16 pages
Review Article

Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells

1Faculty of Medicine, Fayoum University, Cairo, Egypt
2NovaMed Medical Research Association, Cairo, Egypt
3Faculty of Medicine, Ain Shams University, Cairo, Egypt
4Medical Research Group of Egypt, Cairo, Egypt
5Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
6Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan

Correspondence should be addressed to Mohamed M. Abdel-Daim; ge.ude.zeus.tev@m.miadledba

Received 25 February 2017; Accepted 31 May 2017; Published 9 July 2017

Academic Editor: Andreas Daiber

Copyright © 2017 Sara Shaban et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although physiological levels of reactive oxygen species (ROS) are required to maintain the self-renewal capacity of stem cells, elevated ROS levels can induce chromosomal aberrations, mitochondrial DNA damage, and defective stem cell differentiation. Over the past decade, several studies have shown that antioxidants can not only mitigate oxidative stress and improve stem cell survival but also affect the potency and differentiation of these cells. Further beneficial effects of antioxidants include increasing genomic stability, improving the adhesion of stem cells to culture media, and enabling researchers to manipulate stem cell proliferation by using different doses of antioxidants. These findings can have several clinical implications, such as improving neurogenesis in patients with stroke and neurodegenerative diseases, as well as improving the regeneration of infarcted myocardial tissue and the banking of spermatogonial stem cells. This article reviews the cellular and molecular effects of antioxidant supplementation to cultured or transplanted stem cells and draws up recommendations for further research in this area.