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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 5049532, 6 pages
Review Article

Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases

1Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan 31151, Republic of Korea
2Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Republic of Korea

Correspondence should be addressed to Kiyoung Kim;

Received 6 September 2017; Accepted 26 November 2017; Published 24 December 2017

Academic Editor: Sebastien Talbot

Copyright © 2017 Youngjo Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The omega class glutathione S-transferases (GSTOs) are multifunctional enzymes involved in cellular defense and have distinct structural and functional characteristics, which differ from those of other GSTs. Previous studies provided evidence for the neuroprotective effects of GSTOs. However, the molecular mechanisms underpinning the neuroprotective functions of GSTOs have not been fully elucidated. Recently, our genetic and molecular studies using the Drosophila system have suggested that GstO1 has a protective function against H2O2-induced neurotoxicity by regulating the MAPK signaling pathway, and GstO2 is required for the activation of mitochondrial ATP synthase in the Drosophila neurodegenerative disease model. The comprehensive understanding of various neuroprotection mechanisms of Drosophila GstOs from our studies provides valuable insight into the neuroprotective functions of GstOs in vivo. In this review, we briefly introduce recent studies and summarize the novel biological functions and mechanisms underpinning neuroprotective effects of GstOs in Drosophila.